Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_26(antitoxin)
Location 2291009..2291803 Replicon chromosome
Accession NZ_LR735437
Organism Staphylococcus epidermidis strain none isolate Se_BPH0723

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag GOZ17_RS11250 Protein ID WP_049371062.1
Coordinates 2291333..2291803 (+) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag GOZ17_RS11245 Protein ID WP_053091513.1
Coordinates 2291009..2291320 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GOZ17_RS11205 2286642..2287316 - 675 WP_002439166.1 hypothetical protein -
GOZ17_RS11210 2287330..2287752 - 423 WP_155976054.1 single-stranded DNA-binding protein -
GOZ17_RS11215 2287752..2288396 - 645 WP_002439164.1 ERF family protein -
GOZ17_RS11220 2288389..2288613 - 225 WP_001830261.1 DUF2483 family protein -
GOZ17_RS11225 2288585..2288860 - 276 WP_021298917.1 chordopoxvirus fusion protein -
GOZ17_RS12925 2289194..2289358 - 165 WP_002502886.1 hypothetical protein -
GOZ17_RS11230 2289372..2290124 - 753 WP_002502887.1 phage antirepressor KilAC domain-containing protein -
GOZ17_RS11235 2290137..2290583 - 447 WP_155976055.1 hypothetical protein -
GOZ17_RS11240 2290622..2290840 - 219 WP_049401132.1 hypothetical protein -
GOZ17_RS11245 2291009..2291320 + 312 WP_053091513.1 helix-turn-helix domain-containing protein Antitoxin
GOZ17_RS11250 2291333..2291803 + 471 WP_049371062.1 ImmA/IrrE family metallo-endopeptidase Toxin
GOZ17_RS11255 2291800..2292615 + 816 WP_049371064.1 DUF5067 domain-containing protein -
GOZ17_RS11260 2292666..2294042 + 1377 WP_155976056.1 recombinase family protein -
GOZ17_RS11265 2294069..2295271 + 1203 Protein_2105 FAD-dependent oxidoreductase -
GOZ17_RS11270 2295596..2295937 - 342 WP_002438738.1 DUF1450 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2250150..2294042 43892


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(32-118)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 18483.74 Da        Isoelectric Point: 5.3066

>T288888 WP_049371062.1 NZ_LR735437:2291333-2291803 [Staphylococcus epidermidis]
VGKYEDLMIKYDHLPITETKYMPDFMSGLYLDGEIFINDNRSVRQKLETLAEEIAHHKLTHGNITNSDEYNNRKFENYAR
RYAKETVISLDGLIEAHRRGINSLYELSEFFEVTEEYVLDCLNHYKSKYGLSVIHDDYTIYFEPLSVIKNKRRDAE

Download         Length: 471 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 12230.89 Da        Isoelectric Point: 5.3506

>AT288888 WP_053091513.1 NZ_LR735437:2291009-2291320 [Staphylococcus epidermidis]
MSIGNRIKKRRKEMKMSADKLAEKIGKNRATVYRYEKDEIENMPYDVLEPIAEALNVSPAYLMGWEEKEKTETVAAHLDY
SDLTEEEQKEVENFIDYIRNRRK

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References