Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 921724..922253 Replicon chromosome
Accession NZ_LR735437
Organism Staphylococcus epidermidis strain none isolate Se_BPH0723

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag GOZ17_RS04425 Protein ID WP_001829891.1
Coordinates 921891..922253 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag GOZ17_RS04420 Protein ID WP_001829931.1
Coordinates 921724..921894 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GOZ17_RS04395 917548..918027 + 480 WP_002469586.1 PH domain-containing protein -
GOZ17_RS04400 918020..919525 + 1506 WP_002457110.1 PH domain-containing protein -
GOZ17_RS04405 919512..920021 + 510 WP_002457109.1 PH domain-containing protein -
GOZ17_RS04410 920069..920422 + 354 WP_002457108.1 holo-ACP synthase -
GOZ17_RS04415 920489..921637 + 1149 WP_002457107.1 alanine racemase -
GOZ17_RS04420 921724..921894 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
GOZ17_RS04425 921891..922253 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
GOZ17_RS04430 922598..923599 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
GOZ17_RS04435 923699..924025 + 327 WP_001829952.1 anti-sigma factor antagonist -
GOZ17_RS04440 924027..924500 + 474 WP_002469585.1 anti-sigma B factor RsbW -
GOZ17_RS04445 924475..925245 + 771 WP_002440602.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T288886 WP_001829891.1 NZ_LR735437:921891-922253 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT288886 WP_001829931.1 NZ_LR735437:921724-921894 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References