Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 910539..911048 Replicon chromosome
Accession NZ_LR735437
Organism Staphylococcus epidermidis strain none isolate Se_BPH0723

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag GOZ17_RS04365 Protein ID WP_001829980.1
Coordinates 910839..911048 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag GOZ17_RS04360 Protein ID WP_001829893.1
Coordinates 910539..910832 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GOZ17_RS04335 905547..906335 + 789 WP_002469583.1 hydroxyethylthiazole kinase -
GOZ17_RS04340 906341..906979 + 639 WP_002505076.1 thiamine phosphate synthase -
GOZ17_RS04345 907068..907940 + 873 WP_002470121.1 membrane protein insertase YidC -
GOZ17_RS04350 908046..908699 - 654 WP_001829983.1 HD domain-containing protein -
GOZ17_RS04355 908881..910365 - 1485 WP_002457116.1 cardiolipin synthase -
GOZ17_RS04360 910539..910832 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
GOZ17_RS04365 910839..911048 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
GOZ17_RS04370 911191..911328 + 138 WP_001829949.1 hypothetical protein -
GOZ17_RS04375 911427..912638 - 1212 WP_155976030.1 rod shape-determining protein RodA -
GOZ17_RS04380 913029..914102 + 1074 WP_002468311.1 D-alanine--D-alanine ligase -
GOZ17_RS04385 914114..915469 + 1356 WP_002457113.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T288885 WP_001829980.1 NZ_LR735437:910839-911048 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT288885 WP_001829893.1 NZ_LR735437:910539-910832 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References