Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 53146..53664 Replicon chromosome
Accession NZ_LR735434
Organism Staphylococcus epidermidis strain none isolate Se_BPH0736

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag GOZ11_RS00235 Protein ID WP_002437527.1
Coordinates 53146..53355 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A1L8Y5R0
Locus tag GOZ11_RS00240 Protein ID WP_002437530.1
Coordinates 53371..53664 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GOZ11_RS00210 48250..49391 + 1142 WP_089418807.1 IS3 family transposase -
GOZ11_RS00215 49312..49623 - 312 WP_155974606.1 hypothetical protein -
GOZ11_RS00220 49607..50908 - 1302 WP_000456234.1 restriction endonuclease subunit S -
GOZ11_RS00225 50898..52412 - 1515 WP_000190901.1 type I restriction-modification system subunit M -
GOZ11_RS00230 52896..53033 - 138 WP_002437525.1 hypothetical protein -
GOZ11_RS00235 53146..53355 - 210 WP_002437527.1 heavy-metal-associated domain-containing protein Toxin
GOZ11_RS00240 53371..53664 - 294 WP_002437530.1 copper-sensing transcriptional repressor CsoR Antitoxin
GOZ11_RS00245 53831..55345 + 1515 WP_155974654.1 cardiolipin synthase -
GOZ11_RS00250 55380..56027 + 648 WP_002437536.1 HD domain-containing protein -
GOZ11_RS00255 56305..57996 + 1692 WP_155974607.1 IS1182 family transposase -
GOZ11_RS00260 57987..58247 - 261 WP_001549961.1 DUF3387 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside SCCmec mecA / fosB icaC / icaA / icaR / aur / esaD 38901..322346 283445


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-67)

Antitoxin

Metal-sensitive transcriptional repressor

(16-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7944.05 Da        Isoelectric Point: 4.1598

>T288882 WP_002437527.1 NZ_LR735434:c53355-53146 [Staphylococcus epidermidis]
MLNSNIVFIDNIETKEQAQMLNERLLNMIGVHTVSIDIERNMVNVEYETPTNLNSIEKEIYDAGFKVLS

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11231.84 Da        Isoelectric Point: 6.3270

>AT288882 WP_002437530.1 NZ_LR735434:c53664-53371 [Staphylococcus epidermidis]
MENQNHAHHSEQVKLNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVATKLLEHHMKSCIMEKINQGTE
EEAMEELLVTFQKLVKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1L8Y5R0

References