Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 880145..880654 Replicon chromosome
Accession NZ_LR735432
Organism Staphylococcus epidermidis strain none isolate Se_RP62a-WT

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag GOZ24_RS04245 Protein ID WP_001829980.1
Coordinates 880445..880654 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag GOZ24_RS04240 Protein ID WP_001829893.1
Coordinates 880145..880438 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GOZ24_RS04215 875153..875941 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
GOZ24_RS04220 875947..876585 + 639 WP_002505076.1 thiamine phosphate synthase -
GOZ24_RS04225 876674..877546 + 873 WP_002458703.1 membrane protein insertase YidC -
GOZ24_RS04230 877652..878305 - 654 WP_001829983.1 HD domain-containing protein -
GOZ24_RS04235 878487..879971 - 1485 WP_002457116.1 cardiolipin synthase -
GOZ24_RS04240 880145..880438 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
GOZ24_RS04245 880445..880654 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
GOZ24_RS04250 880797..880934 + 138 WP_001829949.1 hypothetical protein -
GOZ24_RS04255 881033..882244 - 1212 WP_002486299.1 rod shape-determining protein RodA -
GOZ24_RS04260 882635..883708 + 1074 WP_001832735.1 D-alanine--D-alanine ligase -
GOZ24_RS04265 883720..885075 + 1356 WP_002457113.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T288878 WP_001829980.1 NZ_LR735432:880445-880654 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT288878 WP_001829893.1 NZ_LR735432:880145-880438 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References