Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 994705..995489 Replicon chromosome
Accession NZ_LR735429
Organism Staphylococcus epidermidis strain none isolate Se_BPH0704

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag GOZ23_RS04910 Protein ID WP_145450220.1
Coordinates 995328..995489 (+) Length 54 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0E1VBD1
Locus tag GOZ23_RS04905 Protein ID WP_002446763.1
Coordinates 994705..995304 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GOZ23_RS04885 990430..991887 + 1458 WP_002446767.1 ABC transporter substrate-binding protein/permease -
GOZ23_RS04890 991880..992602 + 723 WP_002446766.1 amino acid ABC transporter ATP-binding protein -
GOZ23_RS04895 992950..994080 + 1131 WP_002476052.1 tRNA epoxyqueuosine(34) reductase QueG -
GOZ23_RS04900 994077..994547 + 471 WP_002446764.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
GOZ23_RS04905 994705..995304 + 600 WP_002446763.1 glucosamine-6-phosphate isomerase Antitoxin
GOZ23_RS04910 995328..995489 + 162 WP_145450220.1 hypothetical protein Toxin
GOZ23_RS04915 995662..996066 + 405 WP_145450218.1 hypothetical protein -
GOZ23_RS04920 996250..997635 + 1386 WP_155966397.1 class II fumarate hydratase -
GOZ23_RS04925 998110..998592 + 483 Protein_912 transposase -
GOZ23_RS04930 998765..999589 - 825 WP_145333982.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 998281..998592 311


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(125-195)


Sequences

Toxin        


Download         Length: 54 a.a.        Molecular weight: 6287.82 Da        Isoelectric Point: 4.1589

>T288877 WP_145450220.1 NZ_LR735429:995328-995489 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQPHDNEIR

Download         Length: 162 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22635.54 Da        Isoelectric Point: 4.9942

>AT288877 WP_002446763.1 NZ_LR735429:994705-995304 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLGKEHAPVFDELKKNVENHAVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDVSVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1VBD1

References