Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 854267..854796 Replicon chromosome
Accession NZ_LR735429
Organism Staphylococcus epidermidis strain none isolate Se_BPH0704

Toxin (Protein)


Gene name mazF Uniprot ID A0A939SRT1
Locus tag GOZ23_RS04080 Protein ID WP_002447757.1
Coordinates 854434..854796 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag GOZ23_RS04075 Protein ID WP_001829931.1
Coordinates 854267..854437 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GOZ23_RS04050 850091..850570 + 480 WP_002447762.1 PH domain-containing protein -
GOZ23_RS04055 850563..852068 + 1506 WP_002447761.1 PH domain-containing protein -
GOZ23_RS04060 852055..852573 + 519 WP_002447760.1 PH domain-containing protein -
GOZ23_RS04065 852612..852965 + 354 WP_002447759.1 holo-ACP synthase -
GOZ23_RS04070 853032..854180 + 1149 WP_099774939.1 alanine racemase -
GOZ23_RS04075 854267..854437 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
GOZ23_RS04080 854434..854796 + 363 WP_002447757.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
GOZ23_RS04085 855142..856143 + 1002 WP_002447756.1 PP2C family protein-serine/threonine phosphatase -
GOZ23_RS04090 856243..856569 + 327 WP_001829952.1 anti-sigma factor antagonist -
GOZ23_RS04095 856571..857050 + 480 WP_002447755.1 anti-sigma B factor RsbW -
GOZ23_RS04100 857025..857795 + 771 WP_002447754.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13483.62 Da        Isoelectric Point: 9.9522

>T288876 WP_002447757.1 NZ_LR735429:854434-854796 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSDSKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT288876 WP_001829931.1 NZ_LR735429:854267-854437 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References