Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 843079..843588 Replicon chromosome
Accession NZ_LR735429
Organism Staphylococcus epidermidis strain none isolate Se_BPH0704

Toxin (Protein)


Gene name TsdT Uniprot ID A0A0E1VPY9
Locus tag GOZ23_RS04020 Protein ID WP_002447767.1
Coordinates 843379..843588 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A829M395
Locus tag GOZ23_RS04015 Protein ID WP_002458700.1
Coordinates 843079..843372 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GOZ23_RS03990 838086..838874 + 789 WP_002475462.1 hydroxyethylthiazole kinase -
GOZ23_RS03995 838880..839518 + 639 WP_002458704.1 thiamine phosphate synthase -
GOZ23_RS04000 839607..840479 + 873 WP_002458703.1 membrane protein insertase YidC -
GOZ23_RS04005 840586..841239 - 654 WP_002475468.1 HD domain-containing protein -
GOZ23_RS04010 841421..842905 - 1485 WP_002447769.1 cardiolipin synthase -
GOZ23_RS04015 843079..843372 + 294 WP_002458700.1 copper-sensing transcriptional repressor CsoR Antitoxin
GOZ23_RS04020 843379..843588 + 210 WP_002447767.1 cation transporter Toxin
GOZ23_RS04025 843732..843869 + 138 WP_001829949.1 hypothetical protein -
GOZ23_RS04030 843968..845179 - 1212 WP_002447766.1 rod shape-determining protein RodA -
GOZ23_RS04035 845570..846643 + 1074 WP_002458698.1 D-alanine--D-alanine ligase -
GOZ23_RS04040 846655..848010 + 1356 WP_002447764.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(10-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 8008.28 Da        Isoelectric Point: 6.4556

>T288875 WP_002447767.1 NZ_LR735429:843379-843588 [Staphylococcus epidermidis]
MKLKKGLIHVSGIKTTEQEKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDCGFRIL

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11082.71 Da        Isoelectric Point: 5.5778

>AT288875 WP_002458700.1 NZ_LR735429:843079-843372 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVAIKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1VPY9

Antitoxin

Source ID Structure
AlphaFold DB A0A829M395

References