Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 984336..985138 Replicon chromosome
Accession NZ_LR735421
Organism Staphylococcus epidermidis strain none isolate Se_BPH0697

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag GOZ25_RS04855 Protein ID WP_002468490.1
Coordinates 984959..985138 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag GOZ25_RS04850 Protein ID WP_002486232.1
Coordinates 984336..984935 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GOZ25_RS04830 979548..981005 + 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -
GOZ25_RS04835 980998..981720 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
GOZ25_RS12550 982217..982366 + 150 WP_002468809.1 hypothetical protein -
GOZ25_RS04840 982581..983711 + 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
GOZ25_RS04845 983708..984178 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
GOZ25_RS04850 984336..984935 + 600 WP_002486232.1 glucosamine-6-phosphate isomerase Antitoxin
GOZ25_RS04855 984959..985138 + 180 WP_002468490.1 hypothetical protein Toxin
GOZ25_RS04860 985294..985698 + 405 WP_002485605.1 hypothetical protein -
GOZ25_RS04865 985883..987268 + 1386 WP_001829862.1 class II fumarate hydratase -
GOZ25_RS04870 987629..988453 - 825 WP_001829804.1 RluA family pseudouridine synthase -
GOZ25_RS04875 988612..989745 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T288871 WP_002468490.1 NZ_LR735421:984959-985138 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22695.55 Da        Isoelectric Point: 4.8641

>AT288871 WP_002486232.1 NZ_LR735421:984336-984935 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGNLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure

References