Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3738469..3738998 Replicon chromosome
Accession NZ_LR699570
Organism Mycobacterium tuberculosis variant bovis strain Mb3601 isolate 14Z005608

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag MBS3601_RS17370 Protein ID WP_003417760.1
Coordinates 3738741..3738998 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag MBS3601_RS17365 Protein ID WP_003417757.1
Coordinates 3738469..3738744 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MBS3601_RS17340 3733494..3734798 - 1305 WP_010950875.1 PPE family protein -
MBS3601_RS17345 3735267..3736704 - 1438 Protein_3425 FAD-binding oxidoreductase -
MBS3601_RS17350 3736807..3737196 + 390 WP_010950876.1 DUF732 domain-containing protein -
MBS3601_RS17355 3737210..3737503 - 294 WP_003417749.1 DUF3017 domain-containing protein -
MBS3601_RS17360 3737500..3738345 - 846 WP_010950877.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
MBS3601_RS17365 3738469..3738744 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
MBS3601_RS17370 3738741..3738998 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
MBS3601_RS17375 3739040..3740230 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
MBS3601_RS17380 3740347..3740715 + 369 WP_003417765.1 FHA domain-containing protein -
MBS3601_RS17385 3740712..3741263 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
MBS3601_RS17390 3741270..3741851 - 582 WP_003417769.1 ATP/GTP-binding protein -
MBS3601_RS17395 3741832..3742200 - 369 WP_003417772.1 DUF742 domain-containing protein -
MBS3601_RS17400 3742178..3742570 - 393 WP_011799344.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T288863 WP_003417760.1 NZ_LR699570:3738741-3738998 [Mycobacterium tuberculosis variant bovis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT288863 WP_003417757.1 NZ_LR699570:3738469-3738744 [Mycobacterium tuberculosis variant bovis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References