Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3151794..3152481 Replicon chromosome
Accession NZ_LR699570
Organism Mycobacterium tuberculosis variant bovis strain Mb3601 isolate 14Z005608

Toxin (Protein)


Gene name vapC Uniprot ID P65044
Locus tag MBS3601_RS14820 Protein ID WP_003414624.1
Coordinates 3152038..3152481 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TFH0
Locus tag MBS3601_RS14815 Protein ID WP_003414620.1
Coordinates 3151794..3152051 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MBS3601_RS14795 3147114..3147968 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
MBS3601_RS14800 3148024..3149187 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
MBS3601_RS14805 3149204..3150418 - 1215 WP_003414610.1 zinc metalloprotease Rip -
MBS3601_RS14810 3150426..3151667 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
MBS3601_RS14815 3151794..3152051 + 258 WP_003414620.1 ribbon-helix-helix domain-containing protein Antitoxin
MBS3601_RS14820 3152038..3152481 + 444 WP_003414624.1 type II toxin-antitoxin system VapC family toxin Toxin
MBS3601_RS14825 3152561..3153223 + 663 WP_003414630.1 cell surface glycolipoprotein Mpt83 -
MBS3601_RS14830 3153319..3153510 + 192 WP_003414632.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MBS3601_RS14835 3153842..3155590 + 1749 WP_003912869.1 cytochrome c biogenesis protein DipZ -
MBS3601_RS14840 3155686..3156267 + 582 WP_003414644.1 fasciclin domain-containing protein -
MBS3601_RS14845 3156367..3156633 + 267 WP_031657293.1 DUF2631 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 16595.72 Da        Isoelectric Point: 6.4890

>T288860 WP_003414624.1 NZ_LR699570:3152038-3152481 [Mycobacterium tuberculosis variant bovis]
MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPDSVLAGFIRVVTNRRVFTEPTSPQDAWQAVDALLAAPAAM
RLRPGERHWMAFRQLASDVDANGNDIADAHLAAYALENNATWLSADRGFARFRRLRWRHPLDGQTHL

Download         Length: 444 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9013.22 Da        Isoelectric Point: 10.8344

>AT288860 WP_003414620.1 NZ_LR699570:3151794-3152051 [Mycobacterium tuberculosis variant bovis]
VRTTIRIDDELYREVKAKAARSGRTVAAVLEDAVRRGLNPPKPQAAGRYRVQPSGKGGLRPGVDLSSNAALAEAMNDGVS
VDAVR

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VWO

Antitoxin

Source ID Structure
PDB 7VWO
AlphaFold DB G0TFH0

References