Detailed information of TA system TA028886

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1384333..1385021
• Replicon: chromosome
• Accession: NC_020245
• Organism: Mycobacterium bovis BCG str. Korea 1168P

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: K60_RS06570
• Protein ID: WP_003406304.1
• Coordinates: 1384590..1385021 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0THR6
• Locus tag: K60_RS06565
• Protein ID: WP_003406302.1
• Coordinates: 1384333..1384593 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K60_RS06545	1379910..1380734	+	825	WP_003900298.1	trehalose ABC transporter permease SugB	-
K60_RS06550	1380739..1381920	+	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
K60_RS06555	1381997..1383097	-	1101	WP_003406300.1	magnesium/cobalt transporter CorA	-
K60_RS06560	1383268..1384257	+	990	WP_003406301.1	malate dehydrogenase	-
K60_RS06565	1384333..1384593	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
K60_RS06570	1384590..1385021	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
K60_RS06575	1385044..1386732	-	1689	WP_003910308.1	PE family protein	-
K60_RS06580	1386912..1387772	+	861	WP_003406306.1	hypothetical protein	-
K60_RS06585	1387853..1388683	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
K60_RS06590	1388740..1389033	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	-
K60_RS06595	1389030..1389299	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T28886 WP_003406304.1 NC_020245:1384590-1385021 [Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T28886 NC_020245:1384590-1385021 [Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9918.25 Da
• Isoelectric Point: 6.4755

>AT28886 WP_003406302.1 NC_020245:1384333-1384593 [Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT28886 NC_020245:1384333-1384593 [Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Structures

Toxin

• AlphaFold DB: G0THR7

Antitoxin

• AlphaFold DB: G0THR6