Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3077126..3077696 Replicon chromosome
Accession NZ_LR699570
Organism Mycobacterium tuberculosis variant bovis strain Mb3601 isolate 14Z005608

Toxin (Protein)


Gene name mazF Uniprot ID P71650
Locus tag MBS3601_RS14435 Protein ID WP_003414166.1
Coordinates 3077126..3077482 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL61
Locus tag MBS3601_RS14440 Protein ID WP_003901465.1
Coordinates 3077466..3077696 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MBS3601_RS14415 3072578..3074266 - 1689 WP_003414155.1 alpha/beta hydrolase family protein -
MBS3601_RS14420 3074270..3074596 - 327 WP_003414157.1 hypothetical protein -
MBS3601_RS14425 3074769..3075356 + 588 WP_003914429.1 DUF3558 family protein -
MBS3601_RS14430 3075375..3077024 + 1650 WP_003899485.1 CocE/NonD family hydrolase -
MBS3601_RS14435 3077126..3077482 - 357 WP_003414166.1 type II toxin-antitoxin system toxin endoribonuclease MazF9 Toxin
MBS3601_RS14440 3077466..3077696 - 231 WP_003901465.1 antitoxin MazE Antitoxin
MBS3601_RS14445 3077739..3078782 - 1044 WP_003414172.1 DUF2293 domain-containing protein -
MBS3601_RS14450 3078973..3079248 + 276 WP_003911993.1 DUF1778 domain-containing protein -
MBS3601_RS14455 3079424..3079678 - 255 WP_003917684.1 hypothetical protein -
MBS3601_RS14460 3079826..3080230 + 405 WP_003414181.1 hypothetical protein -
MBS3601_RS14465 3080227..3080418 + 192 WP_003414184.1 hypothetical protein -
MBS3601_RS14470 3080482..3081771 + 1290 Protein_2855 transposase family protein -
MBS3601_RS14475 3082005..3082262 + 258 WP_003899489.1 hypothetical protein -
MBS3601_RS14480 3082367..3082678 + 312 WP_010950777.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-29)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12858.73 Da        Isoelectric Point: 9.1962

>T288856 WP_003414166.1 NZ_LR699570:c3077482-3077126 [Mycobacterium tuberculosis variant bovis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS

Download         Length: 357 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8231.01 Da        Isoelectric Point: 4.1809

>AT288856 WP_003901465.1 NZ_LR699570:c3077696-3077466 [Mycobacterium tuberculosis variant bovis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L2A
PDB 5HJZ
PDB 6KYT
PDB 6L29
PDB 7DU5
PDB 6KYS

Antitoxin

Source ID Structure
PDB 7DU5
PDB 6KYT
AlphaFold DB A0A7U4FBW3

References