Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3037130..3037809 Replicon chromosome
Accession NZ_LR699570
Organism Mycobacterium tuberculosis variant bovis strain Mb3601 isolate 14Z005608

Toxin (Protein)


Gene name vapC Uniprot ID P9WF90
Locus tag MBS3601_RS14215 Protein ID WP_003414059.1
Coordinates 3037130..3037546 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TF64
Locus tag MBS3601_RS14220 Protein ID WP_003414061.1
Coordinates 3037543..3037809 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MBS3601_RS14195 3033182..3034084 - 903 WP_003900564.1 4-hydroxy-tetrahydrodipicolinate synthase -
MBS3601_RS14200 3034153..3034905 - 753 WP_069523501.1 FAD-dependent thymidylate synthase -
MBS3601_RS14205 3035149..3035424 - 276 WP_003414055.1 type I restriction endonuclease subunit S -
MBS3601_RS14210 3035421..3037043 - 1623 WP_003414057.1 type I restriction-modification system subunit M -
MBS3601_RS14215 3037130..3037546 - 417 WP_003414059.1 type II toxin-antitoxin system toxin ribonuclease C21 Toxin
MBS3601_RS14220 3037543..3037809 - 267 WP_003414061.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MBS3601_RS14225 3037835..3038230 - 396 WP_003414064.1 type II toxin-antitoxin system VapC family toxin -
MBS3601_RS14230 3038227..3038496 - 270 WP_003414066.1 type II toxin-antitoxin system VapB family antitoxin -
MBS3601_RS14235 3038506..3039600 - 1095 WP_003414068.1 restriction endonuclease subunit S -
MBS3601_RS14240 3039597..3040016 - 420 Protein_2809 winged helix-turn-helix domain-containing protein -
MBS3601_RS14245 3040090..3040569 - 480 WP_003414073.1 dihydrofolate reductase -
MBS3601_RS14250 3040640..3041440 - 801 WP_003911953.1 thymidylate synthase -
MBS3601_RS14255 3041596..3042333 + 738 WP_011799288.1 dienelactone hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(16-56)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15773.00 Da        Isoelectric Point: 7.1294

>T288854 WP_003414059.1 NZ_LR699570:c3037546-3037130 [Mycobacterium tuberculosis variant bovis]
MTTRYLLDKSAAYRAHLPAVRHRLEPLMERGLLARCGITDLEFGVSARSREDHRTLGTYRRDALEYVNTPDTVWVRAWEI
QEALTDKGFHRSVKIPDLIIAAVAEHHGIPVMHYDQDFERIAAITRQPVEWVVAPGTA

Download         Length: 417 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9493.77 Da        Isoelectric Point: 7.2783

>AT288854 WP_003414061.1 NZ_LR699570:c3037809-3037543 [Mycobacterium tuberculosis variant bovis]
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5SV2

Antitoxin

Source ID Structure
AlphaFold DB G0TF64

References