Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2847625..2848262 Replicon chromosome
Accession NZ_LR699570
Organism Mycobacterium tuberculosis variant bovis strain Mb3601 isolate 14Z005608

Toxin (Protein)


Gene name vapC Uniprot ID P0DMV7
Locus tag MBS3601_RS13200 Protein ID WP_003413180.1
Coordinates 2847625..2848020 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ44
Locus tag MBS3601_RS13205 Protein ID WP_003413183.1
Coordinates 2848017..2848262 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MBS3601_RS13160 2843710..2844369 + 660 WP_003900846.1 LppA family lipoprotein -
MBS3601_RS13165 2844366..2845025 + 660 WP_003900847.1 hypothetical protein -
MBS3601_RS13170 2845022..2845684 + 663 WP_003900848.1 hypothetical protein -
MBS3601_RS13175 2845681..2845959 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
MBS3601_RS13180 2846052..2846465 + 414 WP_003413164.1 PIN domain nuclease -
MBS3601_RS13185 2846504..2846761 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein -
MBS3601_RS13190 2846758..2847135 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
MBS3601_RS13195 2847151..2847525 - 375 WP_003413177.1 hypothetical protein -
MBS3601_RS13200 2847625..2848020 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 Toxin
MBS3601_RS13205 2848017..2848262 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 Antitoxin
MBS3601_RS13210 2848673..2849092 - 420 WP_003413190.1 A24 family peptidase -
MBS3601_RS13215 2849104..2849931 - 828 WP_010950736.1 shikimate dehydrogenase -
MBS3601_RS13220 2849909..2851162 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
MBS3601_RS13225 2851155..2851667 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endonuclease VapC20-like

(1-129)

Antitoxin

Ribbon-helix-helix protein, CopG

(11-49)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14619.53 Da        Isoelectric Point: 6.9794

>T288852 WP_003413180.1 NZ_LR699570:c2848020-2847625 [Mycobacterium tuberculosis variant bovis]
MIFVDTSFWAALGNAGDARHGTAKRLWASKPPVVMTSNHVLGETWTLLNRRCGHRAAVAAAAIRLSTVVRVEHVTADLEE
QAWEWLVRHDEREYSFVDATSFAVMRKKGIQNAYAFDGDFSAAGFVEVRPE

Download         Length: 396 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9098.33 Da        Isoelectric Point: 5.6007

>AT288852 WP_003413183.1 NZ_LR699570:c2848262-2848017 [Mycobacterium tuberculosis variant bovis]
MLVAYICHVKRLQIYIDEDVDRALAVEARRRRTSKAALIREYVAEHLRQPGPDPVDAFVGSFVGEADLSASVDDVVYGKH
E

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5WZ4
PDB 5WZF

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW31

References