288842

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2222101..2222687 Replicon chromosome
Accession NZ_LR699570
Organism Mycobacterium tuberculosis variant bovis strain Mb3601 isolate 14Z005608

Toxin (Protein)


Gene name mazF Uniprot ID G0TLY3
Locus tag MBS3601_RS10280 Protein ID WP_003410010.1
Coordinates 2222101..2222445 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL58
Locus tag MBS3601_RS10285 Protein ID WP_003410014.1
Coordinates 2222439..2222687 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MBS3601_RS10245 2217807..2218406 + 600 WP_003409989.1 L-lysine exporter -
MBS3601_RS10250 2218822..2219250 + 429 WP_003409992.1 cellulose-binding protein -
MBS3601_RS10255 2219476..2220015 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
MBS3601_RS10260 2220535..2221095 - 561 WP_003410001.1 RES family NAD+ phosphorylase -
MBS3601_RS10265 2221092..2221433 - 342 WP_003410003.1 DUF2384 domain-containing protein -
MBS3601_RS10270 2221519..2221776 + 258 WP_003410006.1 hypothetical protein -
MBS3601_RS10275 2221677..2222012 - 336 WP_003410009.1 dehydrogenase -
MBS3601_RS10280 2222101..2222445 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 Toxin
MBS3601_RS10285 2222439..2222687 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family Antitoxin
MBS3601_RS10290 2222787..2225102 - 2316 WP_003899120.1 cation transporter ATPase CptG -
MBS3601_RS10295 2225099..2225371 - 273 WP_003410017.1 DUF1490 family protein -
MBS3601_RS10300 2225424..2225780 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -
MBS3601_RS10305 2225937..2226704 + 768 WP_003410019.1 hemerythrin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-38)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12230.12 Da        Isoelectric Point: 9.8887

>T288842 WP_003410010.1 NZ_LR699570:c2222445-2222101 [Mycobacterium tuberculosis variant bovis]
VVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTA
IVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL

Download         Length: 345 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9290.34 Da        Isoelectric Point: 4.3757

>AT288842 WP_003410014.1 NZ_LR699570:c2222687-2222439 [Mycobacterium tuberculosis variant bovis]
MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQLLTGQIDRALESIHGTDEAEALAVANAYRVLETMDD
EW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5HK3
PDB 5HK0
PDB 5HKC

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAW9

References