288840

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2213209..2213897 Replicon chromosome
Accession NZ_LR699570
Organism Mycobacterium tuberculosis variant bovis strain Mb3601 isolate 14Z005608

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag MBS3601_RS10215 Protein ID WP_003409958.1
Coordinates 2213209..2213628 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag MBS3601_RS10220 Protein ID WP_003409968.1
Coordinates 2213637..2213897 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MBS3601_RS10190 2208215..2208520 + 306 Protein_2013 ABC transporter permease -
MBS3601_RS10195 2208704..2209552 + 849 WP_003409942.1 class I SAM-dependent methyltransferase -
MBS3601_RS10200 2209515..2210960 - 1446 WP_003409946.1 APC family permease -
MBS3601_RS10205 2211139..2211825 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
MBS3601_RS10210 2212016..2212984 - 969 WP_003409956.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
MBS3601_RS10215 2213209..2213628 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
MBS3601_RS10220 2213637..2213897 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MBS3601_RS10225 2214040..2215716 + 1677 WP_010950639.1 PecA family PE domain-processing aspartic protease -
MBS3601_RS10230 2215704..2216357 - 654 WP_003409976.1 cutinase Cfp21 -
MBS3601_RS10235 2216472..2216702 + 231 WP_003409980.1 DUF167 domain-containing protein -
MBS3601_RS10240 2216787..2217698 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
MBS3601_RS10245 2217807..2218406 + 600 WP_003409989.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T288840 WP_003409958.1 NZ_LR699570:c2213628-2213209 [Mycobacterium tuberculosis variant bovis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT288840 WP_003409968.1 NZ_LR699570:c2213897-2213637 [Mycobacterium tuberculosis variant bovis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References