Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2195158..2195861 Replicon chromosome
Accession NZ_LR699570
Organism Mycobacterium tuberculosis variant bovis strain Mb3601 isolate 14Z005608

Toxin (Protein)


Gene name mazF Uniprot ID G0TLK7
Locus tag MBS3601_RS10070 Protein ID WP_003409778.1
Coordinates 2195158..2195487 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TLK8
Locus tag MBS3601_RS10075 Protein ID WP_003409780.1
Coordinates 2195484..2195861 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MBS3601_RS10050 2191541..2192611 + 1071 WP_003899091.1 epoxide hydrolase EphB -
MBS3601_RS10055 2192608..2193123 + 516 WP_003409718.1 flavin reductase family protein -
MBS3601_RS10060 2193120..2194181 + 1062 WP_003899092.1 3,4-dihydroxy-2-butanone-4-phosphate synthase -
MBS3601_RS10065 2194178..2194948 + 771 WP_003409775.1 SDR family oxidoreductase -
MBS3601_RS10070 2195158..2195487 - 330 WP_003409778.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MBS3601_RS10075 2195484..2195861 - 378 WP_003409780.1 type II toxin-antitoxin system antitoxin MazE5 Antitoxin
MBS3601_RS10080 2195858..2196448 - 591 WP_003910477.1 SEC-C domain-containing protein -
MBS3601_RS10085 2196503..2197867 + 1365 WP_003899094.1 HNH endonuclease -
MBS3601_RS10090 2198022..2198474 - 453 WP_010950636.1 lipoprotein -
MBS3601_RS10095 2198538..2198939 + 402 WP_003409869.1 hypothetical protein -
MBS3601_RS10100 2198932..2199114 - 183 WP_003409870.1 hypothetical protein -
MBS3601_RS10105 2199228..2199578 - 351 WP_003409871.1 hypothetical protein -
MBS3601_RS10110 2199589..2200491 - 903 WP_003409874.1 hypothetical protein -
MBS3601_RS10115 2200512..2200703 - 192 WP_003409876.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-103)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 11787.82 Da        Isoelectric Point: 8.5361

>T288837 WP_003409778.1 NZ_LR699570:c2195487-2195158 [Mycobacterium tuberculosis variant bovis]
VTALPARGEVWWCEMAEIGRRPVVVLSRDAAIPRLRRALVAPCTTTIRGLASEVVLEPGSDPIPRRSAVNLDSVESVSVA
VLVNRLGRLADIRMRAICTALEVAVDCSR

Download         Length: 330 bp

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13560.07 Da        Isoelectric Point: 5.1519

>AT288837 WP_003409780.1 NZ_LR699570:c2195861-2195484 [Mycobacterium tuberculosis variant bovis]
VKTARLQVTLRCAVDLINSSSDQCFARIEHVASDQADPRPGVWHSSGMNRIRLSTTVDAALLTSARDMRAGITDAALIDE
ALAALLARHRSAEVDASYAAYDKHPVDEPDEWGDLASWRRAAGDS

Download         Length: 378 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLK7

Antitoxin

Source ID Structure
AlphaFold DB G0TLK8

References