Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1938524..1939137 Replicon chromosome
Accession NZ_LR699570
Organism Mycobacterium tuberculosis variant bovis strain Mb3601 isolate 14Z005608

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag MBS3601_RS08920 Protein ID WP_003408465.1
Coordinates 1938524..1938913 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag MBS3601_RS08925 Protein ID WP_003408469.1
Coordinates 1938910..1939137 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MBS3601_RS08890 1934154..1935068 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
MBS3601_RS08895 1935071..1935901 + 831 WP_003408448.1 cyclase family protein -
MBS3601_RS08900 1935901..1936251 + 351 WP_003898986.1 cupin domain-containing protein -
MBS3601_RS08905 1936304..1937121 + 818 Protein_1757 3-keto-5-aminohexanoate cleavage protein -
MBS3601_RS08910 1937135..1937914 + 780 WP_003408460.1 IclR family transcriptional regulator -
MBS3601_RS08920 1938524..1938913 - 390 WP_003408465.1 PIN domain-containing protein Toxin
MBS3601_RS08925 1938910..1939137 - 228 WP_003408469.1 antitoxin Antitoxin
MBS3601_RS08930 1939355..1940839 + 1485 WP_010950580.1 biotin carboxylase -
MBS3601_RS08935 1940836..1942083 + 1248 WP_003408476.1 serine hydrolase -
MBS3601_RS08940 1942126..1942545 - 420 WP_003408483.1 hypothetical protein -
MBS3601_RS08945 1942535..1943245 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T288835 WP_003408465.1 NZ_LR699570:c1938913-1938524 [Mycobacterium tuberculosis variant bovis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT288835 WP_003408469.1 NZ_LR699570:c1939137-1938910 [Mycobacterium tuberculosis variant bovis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References