Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1575375..1576030 Replicon chromosome
Accession NZ_LR699570
Organism Mycobacterium tuberculosis variant bovis strain Mb3601 isolate 14Z005608

Toxin (Protein)


Gene name vapC Uniprot ID A0A7U4FAR1
Locus tag MBS3601_RS07325 Protein ID WP_003407268.1
Coordinates 1575375..1575776 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TIK2
Locus tag MBS3601_RS07330 Protein ID WP_003407272.1
Coordinates 1575773..1576030 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MBS3601_RS07310 1571219..1572604 - 1386 WP_003407260.1 cytochrome P450 -
MBS3601_RS07315 1572682..1573716 + 1035 WP_003407264.1 AraC family transcriptional regulator -
MBS3601_RS07320 1573762..1575120 - 1359 WP_010950541.1 PE family protein -
MBS3601_RS07325 1575375..1575776 - 402 WP_003407268.1 type II toxin-antitoxin system VapC family toxin Toxin
MBS3601_RS07330 1575773..1576030 - 258 WP_003407272.1 ribbon-helix-helix domain-containing protein Antitoxin
MBS3601_RS07335 1576113..1577072 - 960 WP_003407276.1 alpha/beta hydrolase -
MBS3601_RS07340 1577097..1578059 - 963 WP_003407279.1 alpha/beta hydrolase -
MBS3601_RS07345 1578058..1578795 + 738 WP_031647000.1 lysoplasmalogenase -
MBS3601_RS07350 1578876..1580843 + 1968 WP_003407285.1 primosomal protein N' -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14894.39 Da        Isoelectric Point: 11.6897

>T288832 WP_003407268.1 NZ_LR699570:c1575776-1575375 [Mycobacterium tuberculosis variant bovis]
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQGLQLATLNVWHFPMFEQLKPPFAVPGHRPRA

Download         Length: 402 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9443.58 Da        Isoelectric Point: 6.4631

>AT288832 WP_003407272.1 NZ_LR699570:c1576030-1575773 [Mycobacterium tuberculosis variant bovis]
MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQV
WRATS

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FAR1

Antitoxin

Source ID Structure
AlphaFold DB G0TIK2

References