288831

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel-ATphRel/-
Location 1541382..1542432 Replicon chromosome
Accession NZ_LR699570
Organism Mycobacterium tuberculosis variant bovis strain Mb3601 isolate 14Z005608

Toxin (Protein)


Gene name phRel Uniprot ID G0TIH2
Locus tag MBS3601_RS07175 Protein ID WP_003407164.1
Coordinates 1541382..1542203 (+) Length 274 a.a.

Antitoxin (Protein)


Gene name ATphRel Uniprot ID A0A7U4BTV8
Locus tag MBS3601_RS07180 Protein ID WP_003407167.1
Coordinates 1542196..1542432 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MBS3601_RS07155 1536940..1537602 - 663 WP_010950531.1 hypothetical protein -
MBS3601_RS07160 1537599..1538384 - 786 WP_003407157.1 membrane protein -
MBS3601_RS07165 1538675..1540636 - 1962 WP_010950533.1 sigma-F factor regulator -
MBS3601_RS07170 1540775..1541161 - 387 WP_003407162.1 anti-sigma-F factor antagonist RsfA -
MBS3601_RS07175 1541382..1542203 + 822 WP_003407164.1 GTP pyrophosphokinase family protein Toxin
MBS3601_RS07180 1542196..1542432 + 237 WP_003407167.1 hypothetical protein Antitoxin
MBS3601_RS07185 1542504..1543709 - 1206 WP_003918234.1 serine hydrolase -
MBS3601_RS07190 1544012..1544797 + 786 WP_003407180.1 lipoprotein LprF -
MBS3601_RS07195 1544993..1546462 + 1470 Protein_1416 fatty acid desaturase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(76-174)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 274 a.a.        Molecular weight: 30100.10 Da        Isoelectric Point: 5.8187

>T288831 WP_003407164.1 NZ_LR699570:1541382-1542203 [Mycobacterium tuberculosis variant bovis]
VVVALVGSAIVDLHSRPPWSNNAVRRLGVALRDGVDPPVDCPSYAEVMLWHADLAAEVQDRIEGRSWSASELLVTSRAKS
QDTLLAKLRRRPYLQLNTIQDIAGVRIDADLLLGEQTRLAREIADHFGADQPAIHDLRDHPHAGYRAVHVWLRLPAGRVE
IQIRTILQSLWANFYELLADAYGRGIRYDERPEQLAAGVVPAQLQELVGVMQDASADLAMHEAEWQHCAEIEYPGQRAMA
LGEASKNKATVLATTKFRLERAINEAESAGGGG

Download         Length: 822 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8830.90 Da        Isoelectric Point: 7.3178

>AT288831 WP_003407167.1 NZ_LR699570:1542196-1542432 [Mycobacterium tuberculosis variant bovis]
VGEVAGYVVEYNRRTHVRRITEFATPQEAMEHRLKLEAERTDSNIEIVALVSKSLGTLKQTHSRYFTGEELNVGNGAR

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIH2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BTV8

References