Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1384740..1385428 Replicon chromosome
Accession NZ_LR699570
Organism Mycobacterium tuberculosis variant bovis strain Mb3601 isolate 14Z005608

Toxin (Protein)


Gene name vapC Uniprot ID G0THR7
Locus tag MBS3601_RS06495 Protein ID WP_003406304.1
Coordinates 1384997..1385428 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0THR6
Locus tag MBS3601_RS06490 Protein ID WP_003406302.1
Coordinates 1384740..1385000 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MBS3601_RS06470 1380317..1381141 + 825 WP_003900298.1 trehalose ABC transporter permease SugB -
MBS3601_RS06475 1381146..1382327 + 1182 WP_003406299.1 trehalose ABC transporter ATP-binding protein SugC -
MBS3601_RS06480 1382404..1383504 - 1101 WP_003406300.1 magnesium/cobalt transporter CorA -
MBS3601_RS06485 1383675..1384664 + 990 WP_003406301.1 malate dehydrogenase -
MBS3601_RS06490 1384740..1385000 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 Antitoxin
MBS3601_RS06495 1384997..1385428 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin Toxin
MBS3601_RS06500 1385451..1387138 - 1688 Protein_1282 PE family protein -
MBS3601_RS06505 1387318..1388178 + 861 WP_003406306.1 hypothetical protein -
MBS3601_RS06510 1388259..1389089 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
MBS3601_RS06515 1389146..1389439 - 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE -
MBS3601_RS06520 1389436..1389705 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(2-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15873.08 Da        Isoelectric Point: 5.8838

>T288829 WP_003406304.1 NZ_LR699570:1384997-1385428 [Mycobacterium tuberculosis variant bovis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Download         Length: 432 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9918.25 Da        Isoelectric Point: 6.4755

>AT288829 WP_003406302.1 NZ_LR699570:1384740-1385000 [Mycobacterium tuberculosis variant bovis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0THR7

Antitoxin

Source ID Structure
AlphaFold DB G0THR6

References