Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
Location | 1023901..1024874 | Replicon | chromosome |
Accession | NZ_LR699570 | ||
Organism | Mycobacterium tuberculosis variant bovis strain Mb3601 isolate 14Z005608 |
Toxin (Protein)
Gene name | tacT | Uniprot ID | O05911 |
Locus tag | MBS3601_RS04825 | Protein ID | WP_003404756.1 |
Coordinates | 1024374..1024874 (+) | Length | 167 a.a. |
Antitoxin (Protein)
Gene name | tacA | Uniprot ID | G0TFR4 |
Locus tag | MBS3601_RS04820 | Protein ID | WP_003404754.1 |
Coordinates | 1023901..1024377 (+) | Length | 159 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MBS3601_RS04800 | 1019748..1021019 | - | 1272 | WP_003404747.1 | PPE family protein | - |
MBS3601_RS04805 | 1021034..1021333 | - | 300 | WP_003404748.1 | PE family protein | - |
MBS3601_RS04810 | 1021777..1023558 | + | 1782 | WP_003404749.1 | BCCT family transporter | - |
MBS3601_RS04815 | 1023555..1023812 | + | 258 | WP_003404750.1 | hypothetical protein | - |
MBS3601_RS04820 | 1023901..1024377 | + | 477 | WP_003404754.1 | DUF1778 domain-containing protein | Antitoxin |
MBS3601_RS04825 | 1024374..1024874 | + | 501 | WP_003404756.1 | GNAT family N-acetyltransferase | Toxin |
MBS3601_RS04835 | 1025187..1026506 | - | 1320 | WP_010950468.1 | IS256-like element IS1554 family transposase | - |
MBS3601_RS04840 | 1026794..1027375 | + | 582 | WP_003404760.1 | IS607-like element IS1535 family transposase | - |
MBS3601_RS04845 | 1027375..1029027 | + | 1653 | WP_003404761.1 | IS607 family element transposase accessory protein TnpB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 167 a.a. Molecular weight: 18048.55 Da Isoelectric Point: 7.8659
>T288825 WP_003404756.1 NZ_LR699570:1024374-1024874 [Mycobacterium tuberculosis variant bovis]
VSGYSAPRRISDADDVTSFSSGEPSLDDYLRKRALANHVQGGSRCFVTCRDGRVVGFYALASGSVAHADAPGRVRRNMPD
PVPVILLSRLAVDRKEQGRGLGSHLLRDAIGRCVQAADSIGLRAILVHALHDEARAFYVHFDFEISPTDPLHLMLLMKDA
RALIGD
VSGYSAPRRISDADDVTSFSSGEPSLDDYLRKRALANHVQGGSRCFVTCRDGRVVGFYALASGSVAHADAPGRVRRNMPD
PVPVILLSRLAVDRKEQGRGLGSHLLRDAIGRCVQAADSIGLRAILVHALHDEARAFYVHFDFEISPTDPLHLMLLMKDA
RALIGD
Download Length: 501 bp
Antitoxin
Download Length: 159 a.a. Molecular weight: 17357.95 Da Isoelectric Point: 11.2467
>AT288825 WP_003404754.1 NZ_LR699570:1023901-1024377 [Mycobacterium tuberculosis variant bovis]
MHRAGAAVTANVWCRAGGIRMAPRPVIPVATQQRLRRQADRQSLGGSGLPALNCTPIRHTIDVMATKPERKTERLAARLT
PEQDALIRRAAEAEGTDLTNFTVTAALAHARDVLADRRLFVLTDAAWTEFLAALDRPVSHKPRLEKLFAARSIFDTEG
MHRAGAAVTANVWCRAGGIRMAPRPVIPVATQQRLRRQADRQSLGGSGLPALNCTPIRHTIDVMATKPERKTERLAARLT
PEQDALIRRAAEAEGTDLTNFTVTAALAHARDVLADRRLFVLTDAAWTEFLAALDRPVSHKPRLEKLFAARSIFDTEG
Download Length: 477 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BSZ2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TFR4 |