Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 1014371..1014990 Replicon chromosome
Accession NZ_LR699570
Organism Mycobacterium tuberculosis variant bovis strain Mb3601 isolate 14Z005608

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag MBS3601_RS04770 Protein ID WP_003404726.1
Coordinates 1014556..1014990 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID G0TFQ5
Locus tag MBS3601_RS04765 Protein ID WP_003404724.1
Coordinates 1014371..1014550 (+) Length 60 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MBS3601_RS04750 1009844..1011424 + 1581 WP_011799139.1 serine hydrolase -
MBS3601_RS04755 1011421..1013814 + 2394 WP_003898639.1 cation-translocating P-type ATPase -
MBS3601_RS04760 1014087..1014245 + 159 WP_003404720.1 hypothetical protein -
MBS3601_RS04765 1014371..1014550 + 180 WP_003404724.1 antitoxin Antitoxin
MBS3601_RS04770 1014556..1014990 + 435 WP_003404726.1 SRPBCC family protein Toxin
MBS3601_RS04775 1015088..1015861 + 774 WP_003404735.1 VOC family protein -
MBS3601_RS04780 1015926..1016375 + 450 WP_003404738.1 hypothetical protein -
MBS3601_RS04785 1016510..1016740 - 231 WP_003898642.1 hypothetical protein -
MBS3601_RS04790 1016907..1018415 - 1509 WP_003404742.1 carotenoid oxygenase family protein -
MBS3601_RS04795 1018417..1019655 - 1239 WP_003404744.1 acetyl-CoA acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15754.47 Da        Isoelectric Point: 9.7977

>T288824 WP_003404726.1 NZ_LR699570:1014556-1014990 [Mycobacterium tuberculosis variant bovis]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Download         Length: 435 bp

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6394.06 Da        Isoelectric Point: 4.3059

>AT288824 WP_003404724.1 NZ_LR699570:1014371-1014550 [Mycobacterium tuberculosis variant bovis]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLQDAASNVVGMSDQQS

Download         Length: 180 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB G0TFQ5

References