288823

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 841937..842646 Replicon chromosome
Accession NZ_LR699570
Organism Mycobacterium tuberculosis variant bovis strain Mb3601 isolate 14Z005608

Toxin (Protein)


Gene name vapC Uniprot ID A0A7U4F979
Locus tag MBS3601_RS03940 Protein ID WP_003903160.1
Coordinates 842218..842646 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TEX4
Locus tag MBS3601_RS03935 Protein ID WP_003403834.1
Coordinates 841937..842194 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MBS3601_RS03930 839118..841846 + 2729 Protein_777 PE family protein -
MBS3601_RS03935 841937..842194 + 258 WP_003403834.1 ribbon-helix-helix protein, CopG family Antitoxin
MBS3601_RS03940 842218..842646 + 429 WP_003903160.1 type II toxin-antitoxin system VapC family toxin Toxin
MBS3601_RS03945 842736..842910 - 175 Protein_780 transposase -
MBS3601_RS03950 843023..843268 + 246 WP_003403841.1 hypothetical protein -
MBS3601_RS03955 843337..844221 - 885 WP_011799127.1 3-hydroxyisobutyrate dehydrogenase -
MBS3601_RS03960 844232..845404 - 1173 WP_010950438.1 acyl-CoA dehydrogenase family protein -
MBS3601_RS03965 845411..846943 - 1533 WP_069523346.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-133)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-36)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15799.21 Da        Isoelectric Point: 7.5536

>T288823 WP_003903160.1 NZ_LR699570:842218-842646 [Mycobacterium tuberculosis variant bovis]
MFLLDANVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVWASFLRLATNRRIFEIPSPRAEAFAFVEAVTAQPHHL
PTNPGPRHLVLLRKLCDEADASGDLIPDAVLAAIAVGHHCAVVSLDRDFARFASVRHIRPPL

Download         Length: 429 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9114.28 Da        Isoelectric Point: 10.6530

>AT288823 WP_003403834.1 NZ_LR699570:841937-842194 [Mycobacterium tuberculosis variant bovis]
MRTTVSISDEILAAAKRRARERGQSLGAVIEDALRREFAAAHVGGARPTVPVFDGGTGPRRGIDLTSNRALSEVLDEGLE
LNSRK

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F979

Antitoxin

Source ID Structure
AlphaFold DB G0TEX4

References