Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
Location | 755256..755796 | Replicon | chromosome |
Accession | NZ_LR699570 | ||
Organism | Mycobacterium tuberculosis variant bovis strain Mb3601 isolate 14Z005608 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | P9WII0 |
Locus tag | MBS3601_RS03460 | Protein ID | WP_003403376.1 |
Coordinates | 755256..755564 (-) | Length | 103 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | G0TQE0 |
Locus tag | MBS3601_RS03465 | Protein ID | WP_003403381.1 |
Coordinates | 755551..755796 (-) | Length | 82 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MBS3601_RS03435 | 750571..752076 | + | 1506 | WP_003403360.1 | carotenoid cleavage oxygenase | - |
MBS3601_RS03440 | 752157..753167 | + | 1011 | WP_003911248.1 | ABC transporter ATP-binding protein | - |
MBS3601_RS03445 | 753555..753938 | - | 384 | WP_003403365.1 | ribonuclease VapC6 | - |
MBS3601_RS03450 | 754033..754188 | - | 156 | WP_003403368.1 | type II toxin-antitoxin system VapB family antitoxin | - |
MBS3601_RS03455 | 754264..754980 | - | 717 | WP_003403371.1 | CPBP family intramembrane metalloprotease | - |
MBS3601_RS03460 | 755256..755564 | - | 309 | WP_003403376.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
MBS3601_RS03465 | 755551..755796 | - | 246 | WP_003403381.1 | ribbon-helix-helix protein, CopG family | Antitoxin |
MBS3601_RS03470 | 755906..756343 | - | 438 | WP_003403386.1 | type II toxin-antitoxin system VapC family toxin | - |
MBS3601_RS03475 | 756340..756594 | - | 255 | WP_003911263.1 | antitoxin VapB7 | - |
MBS3601_RS03480 | 756708..759071 | + | 2364 | WP_003403397.1 | arylsulfatase AtsD | - |
MBS3601_RS03485 | 759134..759460 | + | 327 | WP_003403401.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
MBS3601_RS03490 | 759372..759710 | + | 339 | WP_003403405.1 | PIN domain-containing protein | - |
MBS3601_RS03495 | 759707..759880 | + | 174 | WP_003898549.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 103 a.a. Molecular weight: 11320.10 Da Isoelectric Point: 11.6554
>T288820 WP_003403376.1 NZ_LR699570:c755564-755256 [Mycobacterium tuberculosis variant bovis]
MRRGELWFAATPGGDRPVLVLTRDPVADRIGAVVVVALTRTRRGLVSELELTAVENRVPSDCVVNFDNIHTLPRTAFRRR
ITRLSPARLHEACQTLRASTGC
MRRGELWFAATPGGDRPVLVLTRDPVADRIGAVVVVALTRTRRGLVSELELTAVENRVPSDCVVNFDNIHTLPRTAFRRR
ITRLSPARLHEACQTLRASTGC
Download Length: 309 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BSE5 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TQE0 |