Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 710829..711454 Replicon chromosome
Accession NZ_LR699570
Organism Mycobacterium tuberculosis variant bovis strain Mb3601 isolate 14Z005608

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag MBS3601_RS03225 Protein ID WP_003403218.1
Coordinates 711053..711454 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag MBS3601_RS03220 Protein ID WP_003403213.1
Coordinates 710829..711056 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MBS3601_RS03195 706009..706230 - 222 WP_003898525.1 DUF4926 domain-containing protein -
MBS3601_RS03200 706372..706977 + 606 WP_003898526.1 hypothetical protein -
MBS3601_RS03205 706996..709562 - 2567 Protein_635 SEC-C domain-containing protein -
MBS3601_RS03210 709646..710395 + 750 WP_003898528.1 hypothetical protein -
MBS3601_RS03215 710392..710634 + 243 WP_003403210.1 hypothetical protein -
MBS3601_RS03220 710829..711056 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
MBS3601_RS03225 711053..711454 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
MBS3601_RS03230 711583..711666 + 84 Protein_640 galactose-1-phosphate uridylyltransferase -
MBS3601_RS03235 711685..712767 + 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
MBS3601_RS03240 712764..713855 + 1092 WP_003403225.1 galactokinase -
MBS3601_RS03245 714250..715407 + 1158 WP_003903091.1 hypothetical protein -
MBS3601_RS03250 715418..716365 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T288816 WP_003403218.1 NZ_LR699570:711053-711454 [Mycobacterium tuberculosis variant bovis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT288816 WP_003403213.1 NZ_LR699570:710829-711056 [Mycobacterium tuberculosis variant bovis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References