288811

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 444167..445178 Replicon chromosome
Accession NZ_LR699570
Organism Mycobacterium tuberculosis variant bovis strain Mb3601 isolate 14Z005608

Toxin (Protein)


Gene name pezT Uniprot ID L7N5R2
Locus tag MBS3601_RS01915 Protein ID WP_003401859.1
Coordinates 444167..444760 (-) Length 198 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID O53702
Locus tag MBS3601_RS01920 Protein ID WP_003401860.1
Coordinates 444789..445178 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MBS3601_RS01895 439816..441198 + 1383 WP_003898415.1 magnesium transporter -
MBS3601_RS01900 441210..442244 - 1035 WP_003401856.1 class II fructose-bisphosphate aldolase -
MBS3601_RS01905 442340..443023 + 684 WP_010950388.1 VTT domain-containing protein -
MBS3601_RS01910 443012..444142 - 1131 WP_003401858.1 hypothetical protein -
MBS3601_RS01915 444167..444760 - 594 WP_003401859.1 zeta toxin family protein Toxin
MBS3601_RS01920 444789..445178 - 390 WP_003401860.1 hypothetical protein Antitoxin
MBS3601_RS01925 445259..446470 - 1212 WP_003401861.1 VWA domain-containing protein -
MBS3601_RS01930 446476..447078 - 603 WP_003898417.1 SRPBCC family protein -
MBS3601_RS01935 447092..447988 - 897 WP_003401863.1 MoxR family ATPase -
MBS3601_RS01940 447985..448578 - 594 WP_003401864.1 NTP transferase domain-containing protein -
MBS3601_RS01945 448575..449330 - 756 WP_003401865.1 XdhC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-156)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 198 a.a.        Molecular weight: 21344.53 Da        Isoelectric Point: 10.5018

>T288811 WP_003401859.1 NZ_LR699570:c444760-444167 [Mycobacterium tuberculosis variant bovis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Download         Length: 594 bp

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13648.21 Da        Isoelectric Point: 6.0829

>AT288811 WP_003401860.1 NZ_LR699570:c445178-444789 [Mycobacterium tuberculosis variant bovis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Download         Length: 390 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BRU8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BRT0

References