Detailed information of TA system TA288806

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/HTH_IclR(antitoxin)
• Location: 3429727..3431502
• Replicon: chromosome
• Accession: NZ_LR699554
• Organism: Paraburkholderia sp. Msb3 isolate PDMSB31

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: PDMSB3_RS35445
• Protein ID: WP_165189558.1
• Coordinates: 3430612..3431502 (-)
• Length: 297 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: I2IX98
• Locus tag: PDMSB3_RS35440
• Protein ID: WP_007178567.1
• Coordinates: 3429727..3430611 (-)
• Length: 295 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PDMSB3_RS35420	3424913..3426403	-	1491	WP_007178563.1	aldehyde dehydrogenase	-
PDMSB3_RS35425	3426444..3427274	-	831	WP_007178564.1	aspartate dehydrogenase	-
PDMSB3_RS35430	3427267..3428925	-	1659	WP_035516860.1	thiamine pyrophosphate-binding protein	-
PDMSB3_RS35435	3428918..3429727	-	810	WP_007178566.1	SDR family oxidoreductase	-
PDMSB3_RS35440	3429727..3430611	-	885	WP_007178567.1	IclR family transcriptional regulator	Antitoxin
PDMSB3_RS35445	3430612..3431502	-	891	WP_165189558.1	alpha/beta fold hydrolase	Toxin
PDMSB3_RS35450	3431549..3432076	-	528	WP_165189560.1	cupin domain-containing protein	-
PDMSB3_RS35455	3432103..3432870	-	768	WP_007178570.1	SDR family oxidoreductase	-
PDMSB3_RS35460	3432863..3433954	-	1092	WP_007178571.1	aromatic ring-hydroxylating dioxygenase subunit alpha	-
PDMSB3_RS35465	3434003..3434314	-	312	WP_007178572.1	hypothetical protein	-
PDMSB3_RS35470	3434316..3434630	-	315	WP_006047381.1	non-heme iron oxygenase ferredoxin subunit	-
PDMSB3_RS35475	3435071..3436144	+	1074	WP_007178574.1	porin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Alpha/beta hydrolase fold-1 (50-279)

Antitoxin

• Transcription regulator IclR, N-terminal (30-78)

Sequences

Toxin

Protein

• Length: 297 a.a.
• Molecular weight: 31214.31 Da
• Isoelectric Point: 6.7654

>T288806 WP_165189558.1 NZ_LR699554:c3431502-3430612 [Paraburkholderia sp. Msb3]
MSAVPSVTADPHATLEARLARFPAQQIWLASQRAVSYREVDSADSGALPLVLLHGIGSGAASWVQQFEVLGATRRVLAWD
APGYGASTPVAADSPTAADYANVLKEWLDALGIERCVLLGHSLGAIIAGAFAVMHPQRVAGLLLLSPAGGYGAASAEVRN
TKRDQRLAMLNELGPQGLAEQRSTNMLSAHASDEARAWVRWNMARVIPHGYAQATHLLANADLASDLARHQGRINVAVGA
DDTITTPEACERIALAAGTKLQVVPRAGHAGYIEAPAAYTAIIDTFCRTSDGQRSQ

Nucleotide

• Length: 891 bp

Antitoxin

Protein

• Length: 295 a.a.
• Molecular weight: 32650.11 Da
• Isoelectric Point: 6.9986

>AT288806 WP_007178567.1 NZ_LR699554:c3430611-3429727 [Paraburkholderia sp. Msb3]
MTPDTINAERDADDDRNDTNGDTAYRVPGLERGLKILTEFSPREPVLGAPELSKRLKIPRTTVFRLLQTLESLGFLERAD
KDRNYRLGVAVLRLGFEYLSSLELTDLGLPVIEALRTETGLTSHIVIRDGRDVVFVAKAQSHTPIFSSVKVNVGTRLPAH
ATTHGQVLMGDLTLDELKKLYPEPELERFTKQTPTTVDDLYERIRDDARRGFAISESSFERGISVVSAPVRNDTGRIVAV
ITTTIPRHEIDASLLDSGLIDKVRRAADDLSQRLNYRPKGGPNAGSKYMKALGL

Nucleotide

• Length: 885 bp

Structures

Antitoxin

• AlphaFold DB: I2IX98