Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 53208..53842 Replicon plasmid 3
Accession NZ_LR699116
Organism Aquicella lusitana strain SGT-39

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag AQUSIP_RS11635 Protein ID WP_114835515.1
Coordinates 53208..53612 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag AQUSIP_RS11640 Protein ID WP_114835516.1
Coordinates 53612..53842 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AQUSIP_RS11610 48471..49517 - 1047 WP_114835537.1 IS481 family transposase -
AQUSIP_RS11615 49750..50201 - 452 Protein_52 recombinase family protein -
AQUSIP_RS11620 50209..51186 - 978 WP_114835533.1 hypothetical protein -
AQUSIP_RS11625 51352..52398 + 1047 WP_114835537.1 IS481 family transposase -
AQUSIP_RS11630 52450..52791 - 342 WP_114835514.1 hypothetical protein -
AQUSIP_RS11635 53208..53612 - 405 WP_114835515.1 type II toxin-antitoxin system VapC family toxin Toxin
AQUSIP_RS11640 53612..53842 - 231 WP_114835516.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
AQUSIP_RS11645 54189..55019 - 831 WP_114835517.1 hypothetical protein -
AQUSIP_RS11650 55417..56769 + 1353 WP_170131897.1 hypothetical protein -
AQUSIP_RS11655 56851..57897 + 1047 WP_114835537.1 IS481 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..92205 92205
- inside IScluster/Tn - - 43228..57897 14669


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-127)

Antitoxin

SpoVT-AbrB domain

(7-48)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15293.70 Da        Isoelectric Point: 7.2759

>T288801 WP_114835515.1 NZ_LR699116:c53612-53208 [Aquicella lusitana]
MRLRYLLDTNICIYIAKQKPATVMKKFEELEVGQVAMSVITYGELLYGANKSQSPDAAHSKLVELTTLIPALELNNEVAE
HYGDIRRNLEKFGKPIGNNDLWIASHARALDVILVTNNLREFDRVPKLRIENWV

Download         Length: 405 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 9148.43 Da        Isoelectric Point: 7.2061

>AT288801 WP_114835516.1 NZ_LR699116:c53842-53612 [Aquicella lusitana]
MKFAKIFKSGNSQALRLPKEFQFHTKEVEIFRRGNDVILREKPENLRHAFELLSGMPKDFFSDEREDTLPQEREFF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References