Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1749746..1750233 Replicon chromosome
Accession NZ_LR699114
Organism Aquicella lusitana strain SGT-39

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag AQUSIP_RS08120 Protein ID WP_197737845.1
Coordinates 1749746..1749913 (+) Length 56 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag AQUSIP_RS08125 Protein ID WP_114833769.1
Coordinates 1749907..1750233 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AQUSIP_RS08100 1746926..1747783 + 858 WP_114833765.1 prohibitin family protein -
AQUSIP_RS08105 1748024..1748506 - 483 WP_114833777.1 hypothetical protein -
AQUSIP_RS08110 1748532..1749023 - 492 WP_114833766.1 GNAT family N-acetyltransferase -
AQUSIP_RS08115 1749079..1749576 - 498 WP_114833767.1 GNAT family N-acetyltransferase -
AQUSIP_RS08120 1749746..1749913 + 168 WP_197737845.1 type II toxin-antitoxin system HicA family toxin Toxin
AQUSIP_RS08125 1749907..1750233 + 327 WP_114833769.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
AQUSIP_RS08130 1750355..1750631 + 277 Protein_1590 IS30 family transposase -
AQUSIP_RS08135 1750719..1751894 + 1176 WP_148326074.1 ISL3 family transposase -
AQUSIP_RS08145 1752240..1752719 + 480 WP_114835421.1 hypothetical protein -
AQUSIP_RS08150 1752804..1753493 + 690 WP_114835420.1 PAS domain-containing protein -
AQUSIP_RS08155 1753495..1754436 - 942 WP_114835419.1 DMT family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1750719..1751894 1175


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(2-53)

Antitoxin

Uncharacterised protein family HicB

(52-102)


Sequences

Toxin        


Download         Length: 56 a.a.        Molecular weight: 6020.01 Da        Isoelectric Point: 11.2472

>T288799 WP_197737845.1 NZ_LR699114:1749746-1749913 [Aquicella lusitana]
MKTLGAEISGGNDSRVRVALNGVRAVFHRPHPQKETDKGAVVSMRRFLKEAGIKC

Download         Length: 168 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12686.40 Da        Isoelectric Point: 5.9879

>AT288799 WP_114833769.1 NZ_LR699114:1749907-1750233 [Aquicella lusitana]
MLIYKGYMGHVEFDDEADIFHGEVINTRDVITFQGKSVAEIKKAFRESVDDYLAFCKERNEEPEKPFSGKFNLRLDPDLH
RQIYIAAKQNKMSLNQWIAEAIKHHIQE

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References