Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 696640..698195 Replicon chromosome
Accession NZ_LR699114
Organism Aquicella lusitana strain SGT-39

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag AQUSIP_RS03225 Protein ID WP_114833536.1
Coordinates 696640..697947 (-) Length 436 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag AQUSIP_RS03230 Protein ID WP_114833535.1
Coordinates 697950..698195 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AQUSIP_RS03200 691860..692747 - 888 WP_114833541.1 aminoglycoside phosphotransferase family protein -
AQUSIP_RS03205 692794..693003 - 210 WP_114833540.1 hypothetical protein -
AQUSIP_RS03210 693105..693953 - 849 WP_114833539.1 AraC family transcriptional regulator -
AQUSIP_RS03215 694250..695500 - 1251 WP_148326083.1 hypothetical protein -
AQUSIP_RS03220 695835..696446 + 612 WP_114833537.1 glycine zipper 2TM domain-containing protein -
AQUSIP_RS03225 696640..697947 - 1308 WP_114833536.1 type II toxin-antitoxin system HipA family toxin Toxin
AQUSIP_RS03230 697950..698195 - 246 WP_114833535.1 helix-turn-helix domain-containing protein Antitoxin
AQUSIP_RS03240 698972..699370 - 399 WP_147277456.1 hypothetical protein -
AQUSIP_RS03245 699397..699861 - 465 WP_114833533.1 SsrA-binding protein SmpB -
AQUSIP_RS03250 699903..700340 + 438 WP_114833532.1 type II toxin-antitoxin system RatA family toxin -
AQUSIP_RS03255 700333..700623 + 291 WP_114833531.1 RnfH family protein -
AQUSIP_RS03260 700653..700955 - 303 WP_114833530.1 outer membrane protein assembly factor BamE -
AQUSIP_RS03265 701051..701467 + 417 WP_114833529.1 ferric iron uptake transcriptional regulator -
AQUSIP_RS03270 701543..701770 + 228 WP_114833528.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(8-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-67)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 49519.20 Da        Isoelectric Point: 7.4284

>T288797 WP_114833536.1 NZ_LR699114:c697947-696640 [Aquicella lusitana]
MKSRNRILNVLMNGILVGKLEKTTQGSLTFSYDQTWLNTPGARPISLSLPLVKQSFAGDVVYNFFDNLLPDNQQIRARIQ
AKFHVGTNQPFDLLASIGRDCVGAIQLINGEIPIFKKKINFESLEEKEIASILSSYLNNPLGMTDTAEEFRISIAGAQEK
SAFLYHDGKWCRPLGETPTSHIFKLPIGYIQHQQMDLSDSCENEWLCAQIASAFELPVATCEILYFENVKVLAVERFDRK
MASDNTWLMRLPQEDMCQALGISPNLKYQSDGGPGINEIMRLLLGSAAPVADRDMFYRSQVLFWLLAAIDGHAKNFSVFI
EPEGKYRLTPLYDIMSAYPLMAKKQLQEKKIKMAMALQGKNIHYHWHNIQRRHFLETAKAVNYSPERAETILDDMLQQVD
SVIEQVSEKLPKKFPSNISQPLFDGMREMKKKLEK

Download         Length: 1308 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9315.95 Da        Isoelectric Point: 10.1944

>AT288797 WP_114833535.1 NZ_LR699114:c698195-697950 [Aquicella lusitana]
MLIRSPKELALLIVNQRKKLKLSQTEVSNLVGLKQKTISALENKPESTQLDTLFRVLSALNLDIQLLSKDEIPTTKWKEE
W

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References