288793

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 4155031..4155697 Replicon chromosome
Accession NZ_LR699014
Organism Citrobacter werkmanii isolate MGYG-HGUT-02535

Toxin (Protein)


Gene name tad Uniprot ID A0A6N6K5Y9
Locus tag FYC27_RS20170 Protein ID WP_005132818.1
Coordinates 4155338..4155697 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag FYC27_RS20165 Protein ID WP_096758754.1
Coordinates 4155031..4155348 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYC27_RS20130 4150640..4151398 + 759 WP_096758746.1 DeoR/GlpR family DNA-binding transcription regulator -
FYC27_RS20135 4151472..4151744 + 273 WP_096758747.1 DUF3811 domain-containing protein -
FYC27_RS20140 4151741..4152616 - 876 WP_096758748.1 23S rRNA pseudouridine(2604) synthase RluF -
FYC27_RS20145 4152867..4153184 - 318 WP_096758749.1 CcdB family protein -
FYC27_RS20150 4153184..4153477 - 294 WP_096758750.1 type II toxin-antitoxin system CcdA family antitoxin -
FYC27_RS20155 4153574..4153939 - 366 WP_096758751.1 hypothetical protein -
FYC27_RS23795 4154071..4154244 + 174 WP_096758752.1 hypothetical protein -
FYC27_RS20160 4154743..4155021 + 279 WP_096758753.1 putative addiction module antidote protein -
FYC27_RS20165 4155031..4155348 - 318 WP_096758754.1 helix-turn-helix domain-containing protein Antitoxin
FYC27_RS20170 4155338..4155697 - 360 WP_005132818.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FYC27_RS20175 4155911..4156600 + 690 WP_096758755.1 dipeptidase PepE -
FYC27_RS20180 4156729..4158360 - 1632 WP_096758756.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(41-87)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13476.49 Da        Isoelectric Point: 10.3799

>T288793 WP_005132818.1 NZ_LR699014:c4155697-4155338 [Citrobacter werkmanii]
MTKPLYWVGHARKDLQGMPEHVRDTFGFALWLAQQGKQHSQTKPLKGFGGAGVLEVVEDYHGNTWRAVYTIQLKNAVYVL
HVFQKKSVSGKATPKPEINLIYQRLKAAQRHAQESGYVT

Download         Length: 360 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11301.08 Da        Isoelectric Point: 4.7814

>AT288793 WP_096758754.1 NZ_LR699014:c4155348-4155031 [Citrobacter werkmanii]
MSHDVETSSGNVYADLGEYDAEQMQLKAQLAMVIGEILQCKGVTQQQAAEMLGMTQPKLSNLLRGQFRGISEAKMLECLV
KLGRDVAIVVGKEGDVPGTLKVSFG

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6N6K5Y9

Antitoxin

Source ID Structure

References