Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 4056540..4057075 Replicon chromosome
Accession NZ_LR699014
Organism Citrobacter werkmanii isolate MGYG-HGUT-02535

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag FYC27_RS19710 Protein ID WP_096758666.1
Coordinates 4056788..4057075 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D4BKM9
Locus tag FYC27_RS19705 Protein ID WP_006688247.1
Coordinates 4056540..4056791 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYC27_RS19675 4051553..4052401 + 849 WP_135912711.1 alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase PhnJ -
FYC27_RS19680 4052398..4053156 + 759 WP_096758661.1 phosphonate C-P lyase system protein PhnK -
FYC27_RS19685 4053264..4053944 + 681 WP_096758662.1 phosphonate C-P lyase system protein PhnL -
FYC27_RS19690 4053941..4055077 + 1137 WP_096758663.1 alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase -
FYC27_RS19695 4055080..4055625 + 546 WP_096758664.1 ribose 1,5-bisphosphokinase -
FYC27_RS19700 4055698..4056456 + 759 WP_096758665.1 phosphonate metabolism protein PhnP -
FYC27_RS19705 4056540..4056791 + 252 WP_006688247.1 plasmid stabilization protein Antitoxin
FYC27_RS19710 4056788..4057075 + 288 WP_096758666.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FYC27_RS19715 4057072..4057401 - 330 WP_096758667.1 hypothetical protein -
FYC27_RS19720 4057470..4059734 - 2265 WP_096758668.1 hybrid sensor histidine kinase/response regulator -
FYC27_RS19730 4059849..4061372 + 1524 WP_096758669.1 sugar ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11092.00 Da        Isoelectric Point: 10.0828

>T288792 WP_096758666.1 NZ_LR699014:4056788-4057075 [Citrobacter werkmanii]
MSYTVKFREDALKEWQKLDKTIQQQFAKKLKKCCENPHVPSEKLGGIKDCYKIKLRTSGFRLVYQVIDETLVIAVVAVGK
RERSEVYNLASERLR

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9215.53 Da        Isoelectric Point: 4.2965

>AT288792 WP_006688247.1 NZ_LR699014:4056540-4056791 [Citrobacter werkmanii]
MPHIILSDTTASVSELKKNPMATVSAGDGFPVAILNRNQPAFYCVPAELYEKMLDALDDQQLVKLVHERSQQPLVDVDLD
SYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7X1BT32

References