Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 3803372..3804051 Replicon chromosome
Accession NZ_LR699014
Organism Citrobacter werkmanii isolate MGYG-HGUT-02535

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag FYC27_RS18485 Protein ID WP_096758456.1
Coordinates 3803372..3803713 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag FYC27_RS18490 Protein ID WP_096758457.1
Coordinates 3803734..3804051 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYC27_RS18455 3798764..3799090 - 327 WP_003830102.1 DUF1493 family protein -
FYC27_RS18460 3799084..3799532 - 449 Protein_3569 hypothetical protein -
FYC27_RS18470 3800309..3801319 - 1011 WP_096758455.1 Ldh family oxidoreductase -
FYC27_RS18475 3801369..3801929 + 561 Protein_3571 HNH endonuclease -
FYC27_RS18480 3802111..3803118 - 1008 WP_057059518.1 restriction endonuclease -
FYC27_RS18485 3803372..3803713 - 342 WP_096758456.1 TA system toxin CbtA family protein Toxin
FYC27_RS18490 3803734..3804051 - 318 WP_096758457.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FYC27_RS18495 3804070..3804291 - 222 WP_096758458.1 DUF987 family protein -
FYC27_RS18500 3804301..3804777 - 477 WP_096758459.1 RadC family protein -
FYC27_RS18505 3804790..3805248 - 459 WP_096758460.1 antirestriction protein -
FYC27_RS18510 3805344..3805583 - 240 WP_096758461.1 DUF905 domain-containing protein -
FYC27_RS18515 3805661..3806071 - 411 WP_096758462.1 hypothetical protein -
FYC27_RS18520 3806161..3806775 - 615 WP_096758463.1 hypothetical protein -
FYC27_RS18525 3806772..3807476 - 705 WP_096758464.1 WYL domain-containing protein -
FYC27_RS18530 3807678..3808511 - 834 WP_096758465.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3798764..3828429 29665


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-110)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12877.87 Da        Isoelectric Point: 8.9922

>T288789 WP_096758456.1 NZ_LR699014:c3803713-3803372 [Citrobacter werkmanii]
MKTLPATTPQAAKLCLSPVSVWQMLLTRLLEQHYGLTLNDTPFSDETVIQEHINAGITLADAVNFLVDKYELVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLKRNRINATL

Download         Length: 342 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11835.41 Da        Isoelectric Point: 6.4753

>AT288789 WP_096758457.1 NZ_LR699014:c3804051-3803734 [Citrobacter werkmanii]
MSNITWGLQRDITPHLGARLVQEGNRLHYLADRASITGKFSDAECLKLDEAFPHFISQMESMLTTGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYIYIAVYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References