Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3265506..3266126 Replicon chromosome
Accession NZ_LR699014
Organism Citrobacter werkmanii isolate MGYG-HGUT-02535

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag FYC27_RS16045 Protein ID WP_002892050.1
Coordinates 3265908..3266126 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag FYC27_RS16040 Protein ID WP_096758040.1
Coordinates 3265506..3265880 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYC27_RS16030 3260652..3261845 + 1194 WP_096758038.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
FYC27_RS16035 3261868..3265017 + 3150 WP_096758039.1 efflux RND transporter permease AcrB -
FYC27_RS16040 3265506..3265880 + 375 WP_096758040.1 Hha toxicity modulator TomB Antitoxin
FYC27_RS16045 3265908..3266126 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
FYC27_RS16050 3266399..3266872 + 474 WP_096758041.1 YlaC family protein -
FYC27_RS16055 3266946..3267086 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
FYC27_RS16060 3267088..3267348 - 261 WP_096758042.1 type B 50S ribosomal protein L31 -
FYC27_RS16065 3267533..3269086 + 1554 WP_096758043.1 EAL domain-containing protein -
FYC27_RS16070 3269140..3269493 - 354 WP_096758044.1 DUF1428 family protein -
FYC27_RS16075 3269576..3270187 - 612 WP_096758045.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T288788 WP_002892050.1 NZ_LR699014:3265908-3266126 [Citrobacter werkmanii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT288788 WP_096758040.1 NZ_LR699014:3265506-3265880 [Citrobacter werkmanii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSNYGINTQDLQKWRKSGSRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure

References