Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3151595..3152334 Replicon chromosome
Accession NZ_LR699014
Organism Citrobacter werkmanii isolate MGYG-HGUT-02535

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag FYC27_RS15550 Protein ID WP_096757948.1
Coordinates 3151595..3152080 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag FYC27_RS15555 Protein ID WP_096757949.1
Coordinates 3152068..3152334 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYC27_RS15525 3147110..3147763 + 654 WP_096757942.1 enterobactin synthase subunit EntD -
FYC27_RS15530 3147753..3148832 - 1080 WP_096757943.1 alpha/beta hydrolase -
FYC27_RS15535 3148916..3149620 - 705 WP_096757944.1 GNAT family N-acetyltransferase -
FYC27_RS15540 3149888..3151006 + 1119 WP_096757946.1 glutamate--cysteine ligase -
FYC27_RS15545 3151073..3151321 + 249 WP_096757947.1 DUF1158 family protein -
FYC27_RS15550 3151595..3152080 - 486 WP_096757948.1 GNAT family N-acetyltransferase Toxin
FYC27_RS15555 3152068..3152334 - 267 WP_096757949.1 DUF1778 domain-containing protein Antitoxin
FYC27_RS15560 3152490..3152831 - 342 WP_096757950.1 RamA family antibiotic efflux transcriptional regulator -
FYC27_RS15565 3152848..3153960 - 1113 WP_096757951.1 MBL fold metallo-hydrolase -
FYC27_RS15570 3154150..3154731 + 582 WP_096757952.1 TetR/AcrR family transcriptional regulator -
FYC27_RS15575 3154731..3155099 + 369 WP_096757953.1 MmcQ/YjbR family DNA-binding protein -
FYC27_RS15580 3155219..3155872 + 654 WP_096757954.1 oxygen-insensitive NAD(P)H nitroreductase -
FYC27_RS15585 3155937..3157181 + 1245 WP_096757955.1 mechanosensitive ion channel family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(28-152)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17732.53 Da        Isoelectric Point: 10.0703

>T288787 WP_096757948.1 NZ_LR699014:c3152080-3151595 [Citrobacter werkmanii]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQIAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVELSFRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQQRTLFLKLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10104.52 Da        Isoelectric Point: 4.3952

>AT288787 WP_096757949.1 NZ_LR699014:c3152334-3152068 [Citrobacter werkmanii]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILERRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References