Detailed information of TA system TA288785

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 2006616..2007255
• Replicon: chromosome
• Accession: NZ_LR699014
• Organism: Citrobacter werkmanii isolate MGYG-HGUT-02535

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: FYC27_RS09825
• Protein ID: WP_096756975.1
• Coordinates: 2006616..2006792 (+)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: FYC27_RS09830
• Protein ID: WP_137398867.1
• Coordinates: 2006839..2007255 (+)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYC27_RS09805	2003397..2003627	-	231	WP_096756971.1	DUF2554 family protein	-
FYC27_RS09810	2003814..2003939	-	126	WP_096756972.1	DUF2474 domain-containing protein	-
FYC27_RS09815	2003939..2004949	-	1011	WP_096756973.1	cytochrome d ubiquinol oxidase subunit II	-
FYC27_RS09820	2004949..2006352	-	1404	WP_096756974.1	cytochrome ubiquinol oxidase subunit I	-
FYC27_RS09825	2006616..2006792	+	177	WP_096756975.1	type II toxin-antitoxin system HicA family toxin	Toxin
FYC27_RS09830	2006839..2007255	+	417	WP_137398867.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FYC27_RS09835	2007349..2008758	+	1410	WP_096756977.1	PLP-dependent aminotransferase family protein	-
FYC27_RS09840	2009089..2010234	+	1146	WP_096756978.1	ABC transporter substrate-binding protein	-
FYC27_RS09845	2010251..2011267	+	1017	WP_096756979.1	ABC transporter ATP-binding protein	-
FYC27_RS09850	2011268..2012212	+	945	WP_096756980.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-68)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6737.76 Da
• Isoelectric Point: 11.2510

>T288785 WP_096756975.1 NZ_LR699014:2006616-2006792 [Citrobacter werkmanii]
VKQSEFRRWLESQGVDITHGSNHVKLRYQGRRSVMPRHPGDEIKEALRKAILKQLGLS

Nucleotide

• Length: 177 bp

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15171.31 Da
• Isoelectric Point: 4.4938

>AT288785 WP_137398867.1 NZ_LR699014:2006839-2007255 [Citrobacter werkmanii]
MRYPVNLKPAVEGGFVVSFPDIPEALTQGDSRHEALEAAQDALVTAFEFYFDDNETIPLPSAVDAADDYVEIPLSVASKV
LLLNTFLEAKITQQELASRIGRPKQEITRLFDLKHATKIDAVQAAVRALGKQLSLTMQ

Nucleotide

• Length: 417 bp