Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 4980720..4981389 Replicon chromosome
Accession NZ_LR699009
Organism Pluralibacter gergoviae isolate MGYG-HGUT-02520

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag FYC31_RS23420 Protein ID WP_071883348.1
Coordinates 4980720..4981082 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag FYC31_RS23425 Protein ID WP_043082499.1
Coordinates 4981072..4981389 (+) Length 106 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYC31_RS23400 4976795..4978345 + 1551 WP_045287224.1 membrane-bound lytic murein transglycosylase MltF -
FYC31_RS23405 4978342..4978803 - 462 WP_196300365.1 tRNA adenosine(34) deaminase TadA -
FYC31_RS23410 4978908..4979543 - 636 WP_048254444.1 phosphatidylglycerophosphatase C -
FYC31_RS23415 4979788..4980636 + 849 WP_048254442.1 MurR/RpiR family transcriptional regulator -
FYC31_RS23420 4980720..4981082 + 363 WP_071883348.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FYC31_RS23425 4981072..4981389 + 318 WP_043082499.1 helix-turn-helix domain-containing protein Antitoxin
FYC31_RS23430 4981569..4981829 + 261 WP_048254441.1 YfhL family 4Fe-4S dicluster ferredoxin -
FYC31_RS23435 4981826..4982206 - 381 WP_043082497.1 holo-ACP synthase -
FYC31_RS23440 4982206..4982937 - 732 WP_043082496.1 pyridoxine 5'-phosphate synthase -
FYC31_RS23445 4982958..4983683 - 726 WP_043082495.1 DNA repair protein RecO -
FYC31_RS23450 4983695..4984600 - 906 WP_045287229.1 GTPase Era -
FYC31_RS23455 4984597..4985277 - 681 WP_043082493.1 ribonuclease III -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(14-107)

Antitoxin

(31-87)


Sequences


Toxin        


Download         Length: 121 a.a.        Molecular weight: 13417.17 Da        Isoelectric Point: 9.8076

>T288769 WP_071883348.1 NZ_LR699009:4980720-4981082 [Pluralibacter gergoviae]
ITQKSLYWVGSSRKDLQSLPDDVQDVFGYALYLAQTGSKHSQSKVLKGFGSAGVLEVVEQFFGSTYRAVYTVKFADAVYV
LHAFQKKSSSGIATPKCDLNKIHERLKAAEDHARRAHHER

Download         Length: 363 bp


Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11384.28 Da        Isoelectric Point: 9.7905

>AT288769 WP_043082499.1 NZ_LR699009:4981072-4981389 [Pluralibacter gergoviae]
MSDNIEVSSGNVYTDLGDKSAEEMLIKAQLAAAIGQIIKSRGLTQEQAAKLIGLTQPKLSNLLRGQFRGISEAKMLECLT
RLGRDIEIVVSKPRQTPGSLKIIFA

Download         Length: 318 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References