Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 2552219..2553117 Replicon chromosome
Accession NZ_LR699009
Organism Pluralibacter gergoviae isolate MGYG-HGUT-02520

Toxin (Protein)


Gene name - Uniprot ID A0A379D4Q7
Locus tag FYC31_RS12120 Protein ID WP_048253037.1
Coordinates 2552659..2553117 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0F0VT04
Locus tag FYC31_RS12115 Protein ID WP_045288665.1
Coordinates 2552219..2552662 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYC31_RS12095 2547518..2548069 + 552 WP_043085211.1 replication initiation negative regulator SeqA -
FYC31_RS12100 2548098..2549738 + 1641 WP_043085209.1 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) -
FYC31_RS12105 2549807..2551258 - 1452 WP_048253035.1 MFS transporter -
FYC31_RS12110 2551358..2552164 + 807 WP_048253036.1 helix-turn-helix transcriptional regulator -
FYC31_RS12115 2552219..2552662 + 444 WP_045288665.1 DUF2384 domain-containing protein Antitoxin
FYC31_RS12120 2552659..2553117 + 459 WP_048253037.1 RES family NAD+ phosphorylase Toxin
FYC31_RS12125 2553141..2554046 + 906 WP_048253038.1 alpha/beta hydrolase -
FYC31_RS12130 2554016..2554900 - 885 WP_043085201.1 EamA family transporter RarD -
FYC31_RS12135 2555130..2555432 - 303 WP_043085200.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS -
FYC31_RS12140 2555455..2555628 - 174 WP_071883418.1 GhoT/OrtT family toxin -
FYC31_RS12145 2555712..2557028 - 1317 WP_106912821.1 putrescine-ornithine antiporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-147)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(37-89)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 16900.55 Da        Isoelectric Point: 5.7172

>T288761 WP_048253037.1 NZ_LR699009:2552659-2553117 [Pluralibacter gergoviae]
VIFYRLTKTRYLMSAWSGQGAREAGGRWNSVGTAMVYLSQMASLTMLETLVHLQAPQLLDAFTLLSIEIPDEQIQTLDRQ
RLPETWSGEEAPAQLALIGDAWIASGVSLALRVPSALSPVEDNCLLNPQHPALFDMMAGVKRIPFRFDTRLK

Download         Length: 459 bp

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16440.81 Da        Isoelectric Point: 8.5740

>AT288761 WP_045288665.1 NZ_LR699009:2552219-2552662 [Pluralibacter gergoviae]
MKLYSPTVTADKSHDPWRAVGLGTGDGIELMGQISLGLEGDVARRISEWADITPAELRRMSGIPNTTFNRSIKARFTAEQ
SERLVRIVRVLERAVDLFEGDKRAAQKWMSEPNRALGWKAPAEVVFSETGALEVMRLITRLEHGVYS

Download         Length: 444 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A379D4Q7

Antitoxin

Source ID Structure
AlphaFold DB A0A0F0VT04

References