Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1223932..1224485 Replicon chromosome
Accession NZ_LR699009
Organism Pluralibacter gergoviae isolate MGYG-HGUT-02520

Toxin (Protein)


Gene name ccdB Uniprot ID A0A379CUA0
Locus tag FYC31_RS05840 Protein ID WP_048254026.1
Coordinates 1224171..1224485 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag FYC31_RS05835 Protein ID WP_048254027.1
Coordinates 1223932..1224168 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYC31_RS05810 1219337..1220968 + 1632 WP_043081630.1 Na/Pi cotransporter family protein -
FYC31_RS05815 1221006..1221818 - 813 WP_048254029.1 shikimate 5-dehydrogenase -
FYC31_RS05820 1222046..1222918 + 873 WP_043081632.1 23S rRNA pseudouridine(2604) synthase RluF -
FYC31_RS05825 1223128..1223466 + 339 WP_080964540.1 helix-turn-helix domain-containing protein -
FYC31_RS05830 1223467..1223739 - 273 WP_048254028.1 DUF3811 domain-containing protein -
FYC31_RS05835 1223932..1224168 + 237 WP_048254027.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
FYC31_RS05840 1224171..1224485 + 315 WP_048254026.1 CcdB family protein Toxin
FYC31_RS05845 1224530..1225453 - 924 WP_048254025.1 ketopantoate/pantoate/pantothenate transporter PanS -
FYC31_RS05850 1225560..1227143 - 1584 WP_048254024.1 RNA repair transcriptional activator RtcR -
FYC31_RS05860 1227590..1228717 + 1128 WP_048254023.1 slipin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11520.48 Da        Isoelectric Point: 6.7131

>T288755 WP_048254026.1 NZ_LR699009:1224171-1224485 [Pluralibacter gergoviae]
MQFTVYGNTGKSAVYPLLIDVTSDIIGQLNRHIAIPLLPLEKYPASQRPERLIPLIRLSDGKEYAVMTHEMASIPVSVLG
PVFCDASHYRPQIKAAIDFLLDGI

Download         Length: 315 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8703.68 Da        Isoelectric Point: 5.6329

>AT288755 WP_048254027.1 NZ_LR699009:1223932-1224168 [Pluralibacter gergoviae]
MSIKQRTTQSVTMTIDRNLLARAREAGINLSAVLAAALSAEVSQYETKKWQVENSAAIEALNQFHDEHGGFSDDYRTF

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A379CUA0

Antitoxin

Source ID Structure

References