Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 811688..812304 Replicon chromosome
Accession NZ_LR699009
Organism Pluralibacter gergoviae isolate MGYG-HGUT-02520

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FYC31_RS03780 Protein ID WP_106912772.1
Coordinates 811688..812059 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1S2BMV8
Locus tag FYC31_RS03785 Protein ID WP_043081486.1
Coordinates 812062..812304 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYC31_RS03765 808925..809827 + 903 WP_043081490.1 formate dehydrogenase subunit beta -
FYC31_RS03770 809824..810459 + 636 WP_043081489.1 formate dehydrogenase cytochrome b556 subunit -
FYC31_RS03775 810731..811660 + 930 WP_043081488.1 formate dehydrogenase accessory protein FdhE -
FYC31_RS03780 811688..812059 - 372 WP_106912772.1 type II toxin-antitoxin system VapC family toxin Toxin
FYC31_RS03785 812062..812304 - 243 WP_043081486.1 ribbon-helix-helix protein, CopG family Antitoxin
FYC31_RS03790 812441..812731 - 291 WP_043081485.1 helix-turn-helix domain-containing protein -
FYC31_RS03795 812979..813920 - 942 WP_043081484.1 fatty acid biosynthesis protein FabY -
FYC31_RS03800 813953..814390 - 438 WP_043081483.1 D-tyrosyl-tRNA(Tyr) deacylase -
FYC31_RS03805 814387..815250 - 864 WP_043081482.1 virulence factor BrkB family protein -
FYC31_RS03810 815255..815845 - 591 WP_048254743.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(16-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13443.48 Da        Isoelectric Point: 9.9871

>T288754 WP_106912772.1 NZ_LR699009:c812059-811688 [Pluralibacter gergoviae]
MDGPAVFDTNILIDLFNNRSEAANAIEQRGPHRAVSLVTWMEVMAGAKKYGQEARTAGVFSLFEVVDINKEIARRSVSLR
ATYGMKLPDAIILATAQARGSALITRNTKDFAGIPGVITPYRF

Download         Length: 372 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9336.59 Da        Isoelectric Point: 4.4247

>AT288754 WP_043081486.1 NZ_LR699009:c812304-812062 [Pluralibacter gergoviae]
ISMILETDVARILLDVSDDVIRRLDGLKQLRDRPRAELLREAIEQYLDRQSPSVLRDALGLWSDGGEDGLVYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1S2BMV8

References