Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 738439..739099 Replicon chromosome
Accession NZ_LR699008
Organism Hafnia alvei isolate MGYG-HGUT-02508

Toxin (Protein)


Gene name cptA Uniprot ID A0A377PEM3
Locus tag FYB81_RS03475 Protein ID WP_043490966.1
Coordinates 738686..739099 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A097QZ09
Locus tag FYB81_RS03470 Protein ID WP_025801623.1
Coordinates 738439..738705 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYB81_RS03450 733707..734357 - 651 WP_025801627.1 hemolysin III family protein -
FYB81_RS03455 735018..735902 + 885 WP_043490960.1 nucleoside-specific channel-forming protein Tsx -
FYB81_RS03460 736104..736922 + 819 WP_043490961.1 shikimate 5-dehydrogenase -
FYB81_RS03465 737071..738060 - 990 WP_043490963.1 tRNA-modifying protein YgfZ -
FYB81_RS03470 738439..738705 + 267 WP_025801623.1 FAD assembly factor SdhE Antitoxin
FYB81_RS03475 738686..739099 + 414 WP_043490966.1 protein YgfX Toxin
FYB81_RS03480 739186..739704 - 519 WP_040046181.1 flavodoxin FldB -
FYB81_RS03485 739909..740808 + 900 WP_043491009.1 site-specific tyrosine recombinase XerD -
FYB81_RS03490 740836..741552 + 717 WP_025801619.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FYB81_RS03495 741558..743291 + 1734 WP_043490968.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-133)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16198.93 Da        Isoelectric Point: 8.1501

>T288743 WP_043490966.1 NZ_LR699008:738686-739099 [Hafnia alvei]
VDQWRCDVRVSWRTQLLLLVTHGILILLILLAPWPENYSFYWLVLLTLVVFECIRSQKQIAKIQGEFSFLADNHIQWQQN
EWELCKTPWISDFGALLPLRSVKPQGTKKRLWIAADSLTPEAWCHLRRTLMQTHQSD

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10345.85 Da        Isoelectric Point: 6.0684

>AT288743 WP_025801623.1 NZ_LR699008:738439-738705 [Hafnia alvei]
MDIGNKSRIHWACRRGMRELDISIMPFFEHEYDSLSDADKQTFVRLLECDDPDLFNWLMNHGSPKDPELAHMVKLIQTRN
KDRGPMAL

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A377PEM3

Antitoxin

Source ID Structure
AlphaFold DB A0A097QZ09

References