288737

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4996460..4997080 Replicon chromosome
Accession NZ_LR699006
Organism Citrobacter freundii isolate MGYG-HGUT-02495

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag FYB80_RS23850 Protein ID WP_002892050.1
Coordinates 4996862..4997080 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag FYB80_RS23845 Protein ID WP_047413009.1
Coordinates 4996460..4996834 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYB80_RS23835 4991606..4992799 + 1194 WP_043015418.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
FYB80_RS23840 4992822..4995971 + 3150 WP_043015417.1 multidrug efflux RND transporter permease subunit -
FYB80_RS23845 4996460..4996834 + 375 WP_047413009.1 Hha toxicity modulator TomB Antitoxin
FYB80_RS23850 4996862..4997080 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
FYB80_RS23855 4997261..4997812 + 552 WP_043015416.1 maltose O-acetyltransferase -
FYB80_RS23860 4997929..4998399 + 471 WP_043015415.1 YlaC family protein -
FYB80_RS23865 4998479..4998619 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
FYB80_RS23870 4998621..4998881 - 261 WP_043015414.1 type B 50S ribosomal protein L31 -
FYB80_RS23875 4999070..5000623 + 1554 WP_047413013.1 EAL domain-containing protein -
FYB80_RS23880 5000675..5001028 - 354 WP_003831033.1 DUF1428 family protein -
FYB80_RS23885 5001093..5001722 - 630 WP_043015412.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T288737 WP_002892050.1 NZ_LR699006:4996862-4997080 [Citrobacter freundii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14441.26 Da        Isoelectric Point: 5.5716

>AT288737 WP_047413009.1 NZ_LR699006:4996460-4996834 [Citrobacter freundii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEENKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure

References