Detailed information of TA system TA288735

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 3673494..3674133
• Replicon: chromosome
• Accession: NZ_LR699006
• Organism: Citrobacter freundii isolate MGYG-HGUT-02495

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: FYB80_RS17490
• Protein ID: WP_047411120.1
• Coordinates: 3673494..3673670 (+)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: FYB80_RS17495
• Protein ID: WP_123915356.1
• Coordinates: 3673717..3674133 (+)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB80_RS17470	3670272..3670502	-	231	WP_043016251.1	DUF2554 family protein	-
FYB80_RS17475	3670692..3670817	-	126	WP_003020230.1	DUF2474 domain-containing protein	-
FYB80_RS17480	3670817..3671827	-	1011	WP_043016252.1	cytochrome d ubiquinol oxidase subunit II	-
FYB80_RS17485	3671827..3673230	-	1404	WP_047411117.1	cytochrome ubiquinol oxidase subunit I	-
FYB80_RS17490	3673494..3673670	+	177	WP_047411120.1	type II toxin-antitoxin system HicA family toxin	Toxin
FYB80_RS17495	3673717..3674133	+	417	WP_123915356.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FYB80_RS17500	3674226..3675635	+	1410	WP_047411123.1	PLP-dependent aminotransferase family protein	-
FYB80_RS17505	3675965..3677110	+	1146	WP_043016257.1	ABC transporter substrate-binding protein	-
FYB80_RS17510	3677127..3678143	+	1017	WP_047411125.1	ABC transporter ATP-binding protein	-
FYB80_RS17515	3678144..3679088	+	945	WP_043016259.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-64)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6784.77 Da
• Isoelectric Point: 11.2510

>T288735 WP_047411120.1 NZ_LR699006:3673494-3673670 [Citrobacter freundii]
VKQSEFRRWLESQGVEVTNGSNHLKLRYQGRRSVMPRHPGDEIKEALRKAIQKQLGLQ

Nucleotide

• Length: 177 bp

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15002.27 Da
• Isoelectric Point: 4.5468

>AT288735 WP_123915356.1 NZ_LR699006:3673717-3674133 [Citrobacter freundii]
MRYPVNLVPAVEGGFVVSFPDIPEALTQGETRHDALQAAQAALVTAFEFYFDDNEPIPLPSAVVAGADYVEIPLSVASKV
LLLNAFLESNITQQELANRIGRPKQEITRLFDLKHATKIDAVQIAARALGKELSLAML

Nucleotide

• Length: 417 bp