Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2107404..2108058 Replicon chromosome
Accession NZ_LR699006
Organism Citrobacter freundii isolate MGYG-HGUT-02495

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag FYB80_RS10110 Protein ID WP_043017506.1
Coordinates 2107651..2108058 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID R8WMJ6
Locus tag FYB80_RS10105 Protein ID WP_016154349.1
Coordinates 2107404..2107670 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYB80_RS10075 2102607..2104040 - 1434 WP_043017510.1 6-phospho-beta-glucosidase BglA -
FYB80_RS10080 2104160..2104888 - 729 WP_008785744.1 MurR/RpiR family transcriptional regulator -
FYB80_RS10085 2104941..2105252 + 312 WP_047408909.1 N(4)-acetylcytidine aminohydrolase -
FYB80_RS10090 2105416..2106075 + 660 WP_043017508.1 hemolysin III family protein -
FYB80_RS10095 2106167..2107147 - 981 WP_047408911.1 tRNA-modifying protein YgfZ -
FYB80_RS10105 2107404..2107670 + 267 WP_016154349.1 FAD assembly factor SdhE Antitoxin
FYB80_RS10110 2107651..2108058 + 408 WP_043017506.1 protein YgfX Toxin
FYB80_RS10115 2108158..2108679 - 522 WP_043017505.1 flavodoxin FldB -
FYB80_RS10120 2108793..2109689 + 897 WP_003825519.1 site-specific tyrosine recombinase XerD -
FYB80_RS10125 2109713..2110426 + 714 WP_043017504.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FYB80_RS10130 2110432..2112165 + 1734 WP_047408916.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15891.76 Da        Isoelectric Point: 11.5692

>T288730 WP_043017506.1 NZ_LR699006:2107651-2108058 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMNGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDVGKRQHLWLAADSMDDAEWRDLRRLILQQAKQG

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10557.10 Da        Isoelectric Point: 5.6375

>AT288730 WP_016154349.1 NZ_LR699006:2107404-2107670 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAQLEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB R8WMJ6

References