Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 712000..712625 Replicon chromosome
Accession NC_020245
Organism Mycobacterium bovis BCG str. Korea 1168P

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag K60_RS03230 Protein ID WP_003403218.1
Coordinates 712224..712625 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag K60_RS03225 Protein ID WP_003403213.1
Coordinates 712000..712227 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K60_RS03195 707179..707400 - 222 WP_003898525.1 DUF4926 domain-containing protein -
K60_RS03200 707542..708147 + 606 WP_003898526.1 hypothetical protein -
K60_RS03205 708166..710733 - 2568 WP_003900188.1 SEC-C domain-containing protein -
K60_RS03210 710817..711566 + 750 WP_003898528.1 hypothetical protein -
K60_RS03215 711563..711805 + 243 WP_003403210.1 hypothetical protein -
K60_RS03225 712000..712227 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
K60_RS03230 712224..712625 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
K60_RS22245 712754..712837 + 84 Protein_640 galactose-1-phosphate uridylyltransferase -
K60_RS03235 712856..713938 + 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
K60_RS03240 713935..715026 + 1092 WP_003403225.1 galactokinase -
K60_RS03250 715421..716578 + 1158 WP_003903091.1 hypothetical protein -
K60_RS03255 716589..717536 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T28873 WP_003403218.1 NC_020245:712224-712625 [Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T28873 NC_020245:712224-712625 [Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT28873 WP_003403213.1 NC_020245:712000-712227 [Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT28873 NC_020245:712000-712227 [Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References