Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1959411..1960214 Replicon chromosome
Accession NZ_LR699006
Organism Citrobacter freundii isolate MGYG-HGUT-02495

Toxin (Protein)


Gene name yeeV Uniprot ID A0A6N6JYU3
Locus tag FYB80_RS09390 Protein ID WP_024156451.1
Coordinates 1959411..1959791 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag FYB80_RS09395 Protein ID WP_047408718.1
Coordinates 1959849..1960214 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYB80_RS09365 1955285..1955764 + 480 WP_047408701.1 Hcp family type VI secretion system effector -
FYB80_RS09370 1955993..1956775 - 783 WP_047408704.1 hypothetical protein -
FYB80_RS09375 1957766..1958614 - 849 WP_047408707.1 DUF4942 domain-containing protein -
FYB80_RS09385 1958923..1959414 - 492 WP_047408710.1 hypothetical protein -
FYB80_RS09390 1959411..1959791 - 381 WP_024156451.1 TA system toxin CbtA family protein Toxin
FYB80_RS09395 1959849..1960214 - 366 WP_047408718.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FYB80_RS09400 1960236..1960457 - 222 WP_043017585.1 DUF987 domain-containing protein -
FYB80_RS09405 1960471..1960950 - 480 WP_047408722.1 DNA repair protein RadC -
FYB80_RS09410 1960963..1961436 - 474 WP_047413366.1 antirestriction protein -
FYB80_RS09420 1961705..1962523 - 819 WP_047408730.1 DUF945 domain-containing protein -
FYB80_RS09425 1962641..1962892 - 252 WP_047413368.1 DUF905 family protein -
FYB80_RS09430 1962982..1963515 - 534 WP_024156443.1 DUF4234 domain-containing protein -
FYB80_RS09435 1963579..1964046 - 468 WP_043017583.1 hypothetical protein -
FYB80_RS09440 1964143..1964544 - 402 WP_043017582.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-110)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14263.44 Da        Isoelectric Point: 10.0919

>T288729 WP_024156451.1 NZ_LR699006:c1959791-1959411 [Citrobacter freundii]
MQTLSAIPKRKAPSRPTPVEIWQQLLTYLLKRHYGLSLSDTQFSDEEIITQYIDAGISLSDALNFLVEKSELVRIDRPGF
SIKHQSPFIGVIDILRARRATGLMQRNGYKRITLLIAGNAAQEQHS

Download         Length: 381 bp

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13397.25 Da        Isoelectric Point: 6.2044

>AT288729 WP_047408718.1 NZ_LR699006:c1960214-1959849 [Citrobacter freundii]
MSNPIPPVNHDVSEPWWGLKPGITPCFGARLVQEGNRLHYLADRASIAGVFSDADLRHLDQAFPVLLKQLELMLVSGELN
PRHQHCVTLYAKGLTCEADSLGSHGYIYTAIYPTPDDSITR

Download         Length: 366 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6N6JYU3

Antitoxin

Source ID Structure

References