Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 692168..692703 Replicon chromosome
Accession NZ_LR699006
Organism Citrobacter freundii isolate MGYG-HGUT-02495

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag FYB80_RS03390 Protein ID WP_047406935.1
Coordinates 692416..692703 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D4BKM9
Locus tag FYB80_RS03385 Protein ID WP_006688247.1
Coordinates 692168..692419 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYB80_RS03345 687351..688037 + 687 WP_047413307.1 phosphonate C-P lyase system protein PhnL -
FYB80_RS03350 688034..689170 + 1137 WP_047406916.1 alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase -
FYB80_RS03355 689173..689727 + 555 WP_043018118.1 ribose 1,5-bisphosphokinase -
FYB80_RS03360 689714..690148 + 435 WP_043018117.1 aminoalkylphosphonate N-acetyltransferase -
FYB80_RS03365 690157..690915 + 759 WP_047406919.1 phosphonate metabolism protein PhnP -
FYB80_RS03370 690984..691469 + 486 WP_047406923.1 membrane protein -
FYB80_RS03375 691538..691789 + 252 WP_047406926.1 hypothetical protein -
FYB80_RS03380 691761..692090 + 330 WP_047406929.1 phosphotyrosine protein phosphatase -
FYB80_RS03385 692168..692419 + 252 WP_006688247.1 plasmid stabilization protein Antitoxin
FYB80_RS03390 692416..692703 + 288 WP_047406935.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FYB80_RS03395 692700..693026 - 327 WP_047406937.1 hypothetical protein -
FYB80_RS03400 693096..695360 - 2265 WP_047406940.1 hybrid sensor histidine kinase/response regulator -
FYB80_RS03410 695475..696998 + 1524 WP_047406943.1 sugar ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11074.03 Da        Isoelectric Point: 10.2540

>T288725 WP_047406935.1 NZ_LR699006:692416-692703 [Citrobacter freundii]
MSYTVKFREDALKEWQKLDLAIQQQFAKKLKKCCENPHVPSAKLRGIKDCYKIKLRTSGFRLVYQVIDDTLVIAVVAVGK
RERSEVYNLASERLR

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9215.53 Da        Isoelectric Point: 4.2965

>AT288725 WP_006688247.1 NZ_LR699006:692168-692419 [Citrobacter freundii]
MPHIILSDTTASVSELKKNPMATVSAGDGFPVAILNRNQPAFYCVPAELYEKMLDALDDQQLVKLVHERSQQPLVDVDLD
SYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7X1BT32

References