Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 398893..399664 Replicon chromosome
Accession NZ_LR699006
Organism Citrobacter freundii isolate MGYG-HGUT-02495

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag FYB80_RS01865 Protein ID WP_047406475.1
Coordinates 398893..399282 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag FYB80_RS01870 Protein ID WP_172626128.1
Coordinates 399338..399664 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYB80_RS01835 394138..394500 + 363 WP_047406455.1 endoribonuclease SymE -
FYB80_RS01840 394546..395181 - 636 WP_047406458.1 HNH endonuclease -
FYB80_RS01845 395322..396194 + 873 WP_047406461.1 HNH endonuclease -
FYB80_RS01850 396316..397119 - 804 WP_047406464.1 helix-turn-helix transcriptional regulator -
FYB80_RS01855 397497..397895 - 399 WP_047406467.1 hypothetical protein -
FYB80_RS01860 397964..398806 - 843 WP_047406472.1 DUF4942 domain-containing protein -
FYB80_RS01865 398893..399282 - 390 WP_047406475.1 TA system toxin CbtA family protein Toxin
FYB80_RS01870 399338..399664 - 327 WP_172626128.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FYB80_RS01875 399722..399943 - 222 WP_047406482.1 DUF987 domain-containing protein -
FYB80_RS01880 399958..400437 - 480 WP_047406484.1 DNA repair protein RadC -
FYB80_RS01885 400449..400898 - 450 WP_047406487.1 antirestriction protein -
FYB80_RS01890 400931..401752 - 822 WP_047406489.1 DUF945 domain-containing protein -
FYB80_RS01895 402043..403029 - 987 WP_047406493.1 hypothetical protein -
FYB80_RS01900 403029..403211 - 183 WP_047406496.1 hypothetical protein -
FYB80_RS01905 403864..404475 + 612 WP_047413280.1 inovirus Gp2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 397497..417672 20175


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(4-103)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14545.68 Da        Isoelectric Point: 10.2738

>T288724 WP_047406475.1 NZ_LR699006:c399282-398893 [Citrobacter freundii]
MQTKSSQLMREALSRPSAVGVWQTLLTFLLEHHYGLTLNDTPFSHEQVIQQHIDAGISLADALNFIVEKYELLRTDRPGF
SILTQSPFITPIDILRARKATGLMNRGTYKEVTAITRGQHPQARTSGKR

Download         Length: 390 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12023.74 Da        Isoelectric Point: 6.6233

>AT288724 WP_172626128.1 NZ_LR699006:c399664-399338 [Citrobacter freundii]
ISAPWWGLRRSVSPCFGARLVQEGNRLHYLADRANFDGQFCDADLRHLDQAFPVLMKQLELMLTSGELNSLHQHCVTLYA
KGLTCEADTLGSHGYVYIAIYPTPAVTA

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References